Access the full text.
Sign up today, get DeepDyve free for 14 days.
H. Gratzner (1982)
Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication.Science, 218 4571
E. Castrén, F. Zafra, H. Thoenen, D. Lindholm (1992)
Light regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex.Proceedings of the National Academy of Sciences of the United States of America, 89
D. Lindholm, Eero Castr~n, P. Tsoulfas, R. Kolbeck, M. da, Penha Berzaghi, Axel 'drtner, C. Heisenberg, L. Tesarollo, L. Parada, H. Thoenen (1993)
Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation [published erratum appears in J Cell Biol 1998 Dec 28;143(7):following 2090]The Journal of Cell Biology, 122
F. Gage, P. Batchelor, Karen Chen, D. Chin, G. Higgins, S. Koh, S. Deputy, M. Rosenberg, W. Fischer, A. Bjorklund (1989)
NGF receptor reexpression and NGF-mediated cholinergic neuronal hypertrophy in the damaged adult neostriatumNeuron, 2
R. Segal, Hiroshi Takahashi, R. McKay (1992)
Changes in neurotrophin responsiveness during the development of cerebellar granule neuronsNeuron, 9
M. Hofer, S. Pagliusi, A. Hohn, J. Leibrock, Y. Barde (1990)
Regional distribution of brain‐derived neurotrophic factor mRNA in the adult mouse brain.The EMBO Journal, 9
A. Rodríguez‐Tébar, G. Dechant, Y. Barde (1990)
Binding of brain-derived neurotrophic factor to the nerve growth factor receptorNeuron, 4
J. Altman, A. Winfree (1977)
Postnatal development of the cerebellar cortex in the rat: V. Spatial organization of Purkinje cell perikaryaJournal of Comparative Neurology, 171
N. Rocamora, F. Garcia-Ladona, J. Palacios, G. Mengod (1993)
Differential expression of brain-derived neurotrophic factor, neurotrophin-3, and low-affinity nerve growth factor receptor during the postnatal development of the rat cerebellar system.Brain research. Molecular brain research, 17 1-2
R. Balázs, N. Hack, Ole J∅rgensen (1988)
Stimulation of the N-methyl-d-aspartate receptor has a trophic effect on differentiating cerebellar granule cellsNeuroscience Letters, 87
P. Ernfors, J. Merlio, H. Persson (1992)
Cells Expressing mRNA for Neurotrophins and their Receptors During Embryonic Rat DevelopmentEuropean Journal of Neuroscience, 4
M. Favaron, H. Manev, H. Alho, M. Bertolino, B. Ferret, Alessandro Guidotti, Erminio Costa (1988)
Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex.Proceedings of the National Academy of Sciences of the United States of America, 85 19
Y. Bessho, S. Nakanishi, H. Nawa (1993)
Glutamate receptor agonists enhance the expression of BDNF mRNA in cultured cerebellar granule cells.Brain research. Molecular brain research, 18 3
F. Zafra, D. Lindholm, E. Castrén, J. Hartikka, H. Thoenen (1992)
Regulation of brain-derived neurotrophic factor and nerve growth factor mRNA in primary cultures of hippocampal neurons and astrocytes, 12
C. Hyman, M. Hofer, Y. Barde, M. Juhasz, G. Yancopoulos, S. Squinto, R. Lindsay (1991)
BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigraNature, 350
D. Lindholm, E. Castrén, R. Kiefer, F. Zafra, H. Thoenen (1992)
Transforming growth factor-beta 1 in the rat brain: increase after injury and inhibition of astrocyte proliferationThe Journal of Cell Biology, 117
T. Falkenberg, P. Ernfors, H. Persson, N. Lindefors (1992)
Cortical transynaptic activation of tyrosine kinase receptor trkB messenger RNA expression in rat hippocampusNeuroscience, 51
D. Soppet, E. Escandón, Johnne Maragos, D. Middlemas, Susan Raid, Janet Blair, L. Burton, B. Stanton, D. Kaplan, T. Hunter, K. Nikolics, Luis Parade (1991)
The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptorCell, 65
D. Middlemas, R. Lindberg, T. Hunter (1991)
trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptorsMolecular and Cellular Biology, 11
M. Graham, R. Burgoyne (1991)
N-Methyl-d-aspartate stimulation of the survival of rat cerebellar granule cells in culture is not dependent upon increased c-fos expression and is not mimicked by protein kinase C activationNeuroscience Letters, 130
Y. Barde (1990)
The nerve growth factor family.Progress in growth factor research, 2 4
D. Monaghan, R. Bridges, C. Cotman (1989)
The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system.Annual review of pharmacology and toxicology, 29
P. Somogyi, K. Halasy, J. Somogyi, J. Storm-Mathisen, O. Ottersen (1986)
Quantification of immunogold labelling reveals enrichment of glutamate in mossy and parallel fibre terminals in cat cerebellumNeuroscience, 19
Ferdinando Nicoletti, J. Wroblewski, A. Novelli, H. Alho, Alessandro Guidotti, Erminio Costa (1986)
The activation of inositol phospholipid metabolism as a signal- transducing system for excitatory amino acids in primary cultures of cerebellar granule cells, 6
D. Choi (1988)
Glutamate neurotoxicity and diseases of the nervous systemNeuron, 1
A. Rodríguez‐Tébar, Y. Barde (1988)
Binding characteristics of brain-derived neurotrophic factor to its receptors on neurons from the chick embryo, 8
M. Hatten, M. Lynch, R. Rydel, J. Sanchez, J. Joseph‐Silverstein, D. Moscatelli, D. Rifkin (1988)
In vitro neurite extension by granule neurons is dependent upon astroglial-derived fibroblast growth factor.Developmental biology, 125 2
Rudolf Götz, R. Kolbeck, Friedrich Lottspeich, Y. Barde (1992)
Production and characterization of recombinant mouse neurotrophin-3.European journal of biochemistry, 204 2
C. Heisenberg, H. Thoenen, D. Lindholm (1992)
Tri‐iodothyronine regulates survival and differentiation of rat cerebellar granule neuronsNeuroReport, 3
G. Brewer, C. Cotman (1989)
Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygenBrain Research, 494
Hatten (1988)
In vitro neurite extension by granule neurons is dependent upon astroglial-derived fibroblast growth factorJ. Cell Biol., 125
J. Dussault, J. Ruel (1987)
Thyroid hormones and brain development.Annual review of physiology, 49
R. Klein, V. Nanduri, Shuqian Jing, F. Lamballe, P. Tapley, S. Bryant, C. Cordon-Cardo, K. Jones, L. Reichardt, M. Barbacid (1991)
The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3Cell, 66
Jean Nicholson, Joseph Altman (1972)
The effects of early hypo- and hyperthyroidism on the development of rat cerebellar cortex. I. Cell proliferation and differentiation.Brain research, 44 1
V. Gallo, A. Kingsbury, R. Balázs, O. Jørgensen (1987)
The role of depolarization in the survival and differentiation of cerebellar granule cells in culture, 7
J. Altman (1972)
Postnatal development of the cerebellar cortex in the rat. I. The external germinal layer and the transitional molecular layerJournal of Comparative Neurology, 145
D. Kaplan, D. Martín-Zanca, L. Parada (1991)
Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGFNature, 350
S. Rothman, J. Olney (1986)
Glutamate and the pathophysiology of hypoxic–ischemic brain damageAnnals of Neurology, 19
R. Klein, Shu Jing, V. Nanduri, E. O'rourke, M. Barbacid (1991)
The trk proto-oncogene encodes a receptor for nerve growth factorCell, 65
P. Chomczyński, N. Sacchi (1987)
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.Analytical biochemistry, 162 1
J. Legrand (1979)
Morphogenetic actions of thyroid hormonesTrends in Neurosciences, 2
Ronald Lindsay, E. Shooter, M. Radeke, T. Misko, Georg Dechant, Hans Thoenen, Dan Lindholm (1990)
Nerve Growth Factor Regulates Expression of the Nerve Growth Factor Receptor Gene in Adult Sensory NeuronsEuropean Journal of Neuroscience, 2
F. Zafra, E. Castrén, H. Thoenen, D. Lindholm (1991)
Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons.Proceedings of the National Academy of Sciences of the United States of America, 88 22
M. Greenberg, L. Greene, E. Ziff (1985)
Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells.The Journal of biological chemistry, 260 26
S. Squinto, T. Stitt, T. Aldrich, S. Davis, Stella Blanco, C. Radziejewski, D. Glass, P. Masiakowski, M. Furth, D. Valenzuela, P. Distefano, G. Yancopoulos (1991)
trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factorCell, 65
J. Merlio, P. Ernfors, M. Jaber, H. Persson (1992)
Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous systemNeuroscience, 51
'. AlfredoRodriguez-Tebar, G. Dechant, R. Gotz, Y. Barde (1992)
Binding of neurotrophin‐3 to its neuronal receptors and interactions with nerve growth factor and brain‐derived neurotrophic factor.The EMBO Journal, 11
Ian Pearce, M. Cambray-Deakin, R. Burgoyne (1987)
Glutamate acting on NMDA receptors stimulates neurite outgrowth from cerebellar granule cellsFEBS Letters, 223
F. Lamballe, R. Klein, M. Barbacid (1991)
trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3Cell, 66
R. Burgoyne, M. Cambray-Deakin (1988)
The cellular neurobiology of neuronal development: The cerebellar granule cellBrain Research Reviews, 13
M. Radeke, T. Misko, C. Hsu, L. Herzenberg, E. Shooter (1987)
Gene transfer and molecular cloning of the rat nerve growth factor receptorNature, 325
A. Smits, Michio Kato, B. Westermark, M. Nistér, C. Heldin, Keiko Funa (1991)
Neurotrophic activity of platelet-derived growth factor (PDGF): Rat neuronal cells possess functional PDGF beta-type receptors and respond to PDGF.Proceedings of the National Academy of Sciences of the United States of America, 88 18
B. Lu, M. Yokoyama, C. Dreyfus, I. Black (1991)
Depolarizing stimuli regulate nerve growth factor gene expression in cultured hippocampal neurons.Proceedings of the National Academy of Sciences of the United States of America, 88 14
F. Zafra, B. Hengerer, J. Leibrock, H. Thoenen, D. Lindholm (1990)
Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non‐NMDA glutamate receptors.The EMBO Journal, 9
R. Klein, D. Martín-Zanca, M. Barbacid, L. Parada (1990)
Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system.Development, 109 4
Susan Meakin, Ueli Suter, Catherine Drinkwater, AndrewA. Welcher, E. Shooter (1992)
The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor.Proceedings of the National Academy of Sciences of the United States of America, 89 6
P. Maisonpierre, L. Belluscio, B. Friedman, R. Alderson, S. Wiegand, M. Furth, R. Lindsay, G. Yancopoulos (1990)
NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expressionNeuron, 5
D. Lindholm, R. Heumann, B. Hengerer, H. Thoenen (1988)
Interleukin 1 increases stability and transcription of mRNA encoding nerve growth factor in cultured rat fibroblasts.The Journal of biological chemistry, 263 31
R. Balázs, N. Hack, O. Jørgensen (1990)
Selective stimulation of excitatory amino acid receptor subtypes and the survival of cerebellar granule cells in culture: Effect of kainic acidNeuroscience, 37
C. Legrand, J. Clos (1991)
Biochemical, immunocytochemical and morphological evidence for an interaction between thyroid hormone and nerve growth factor in the developing cerebellum of normal and hypothyroid rats.Developmental neuroscience, 13 6
Middlemas (1991)
TrkB, a neural receptor protein-tyrosine kinase: evidence for full-length and two truncated receptorsMol Cell. Biol, 11
We have studied the effects of different neurotrophins on the survival and proliferation of rat cerebellar granule cells in culture. These neurons express trkB and trkC, the putative neuronal receptors for brain‐derived neurotrophic factor (BDNF) and neurotrophin‐3 (NT‐3) respectively. Binding studies using iodinated BDNF and NT‐3 demonstrated that both BDNF and NT‐3 bind to the cerebellar granule neurons with a similar affinity of ˜ 2x10‐9 M. The number of receptors per granule cell was surprisingly high, ∼30x10‐4 and 2x 105 for BDNF and NT‐3, respectively. Both NT‐3 and BDNF elevated c‐fos mRNA in the granule neurons, but only BDNF up‐regulated the mRNA encoding the low‐affinity neurotrophin receptor (p75). In contrast to NT‐3, BDNF acted as a survival factor for the granule neurons. BDNF also induced sprouting of the granule neurons and significantly protected them against neurotoxicity induced by high (1 mM) glutamate concentrations. Cultured granule neurons also expressed low levels of BDNF mRNA which were increased by kainic acid, a glutamate receptor agonist. Thus, BDNF, but not NT‐3, is a survival factor for cultured cerebellar granule neurons and activation of glutamate receptor(s) up‐regulates BDNF expression in these cells.
European Journal of Neuroscience – Wiley
Published: Nov 1, 1993
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.