What is the most significant result of this study?The tandem cyclization strategy represents a unique and straightforward method to access a 1H‐pyrrolo[2,3‐d]carbazole scaffold, which is the core motif in a series of indole alkaloids. To construct the spiroindolines through the indoleninium intermediate, the inherent tendency of C−C bond migration through Wagner–Meerwein rearrangement to generate a tricyclic fused ring system was circumvented by an instantaneous intramolecular nucleophilic trap to indoleninium via an in situ formed enol species induced by the formation of a more stable conjugate diene moiety. It is expected that such a methodology will find broad applications in the syntheses of various indole alkaloids with 1H‐pyrrolo[2,3‐d]carbazole scaffolds.What was the inspiration for this cover design?Inspired by the ancient Chinese Movable Type, a famous Chinese invention from hundreds of years ago, in which the metal blocks can be used/reused to mass produce various books, our method makes it possible to synthesize various indole alkaloids from simple building blocks. We further depicted our work by combining traditional Chinese fine arts such as ink wash painting and Chinese calligraphy in the background with our newly developed methodology.What other topics are you working on at the moment?Our main research interest is focused on developing new methods to construct important scaffolds of biologically active natural products and heterocycles and on applying our methods to the total syntheses of natural products for the construction of small molecule libraries. This includes ynamide‐based tandem cyclizations to indole alkaloids, gold‐catalyzed pathway‐controllable synthesis to structurally diverse heterocycles as well as water‐resistant Lewis acid‐catalyzed organic reactions.
Chemistry - A European Journal – Wiley
Published: Jan 15, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
All the latest content is available, no embargo periods.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud