Bone marrow origin of complement‐receptor lymphocytes

Bone marrow origin of complement‐receptor lymphocytes Substantial regeneration of complement‐receptor lymphocytes (CRL) took place in lymph nodes of adult thymectomized whole‐body X‐irradiated mice reconstituted with semi‐allogeneic (F1) bone marrow. In the presence of complement, alloantisera directed against the transplanted bone marrow killed more than 95% of the lymphoid cells of such chimeras. Moreover, lymph node cell suspensions and lymphoid tissue sections of neonatally thymectomized or adult thymectomized, irradiated and marrow‐grafted mice contained an increased proportion of CRL. The results concur to establish proof that CRL are of extrathymic, bone marrow origin. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Immunology Wiley

Bone marrow origin of complement‐receptor lymphocytes

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Publisher
Wiley
Copyright
Copyright © 1971 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN
0014-2980
eISSN
1521-4141
DOI
10.1002/eji.1830010617
Publisher site
See Article on Publisher Site

Abstract

Substantial regeneration of complement‐receptor lymphocytes (CRL) took place in lymph nodes of adult thymectomized whole‐body X‐irradiated mice reconstituted with semi‐allogeneic (F1) bone marrow. In the presence of complement, alloantisera directed against the transplanted bone marrow killed more than 95% of the lymphoid cells of such chimeras. Moreover, lymph node cell suspensions and lymphoid tissue sections of neonatally thymectomized or adult thymectomized, irradiated and marrow‐grafted mice contained an increased proportion of CRL. The results concur to establish proof that CRL are of extrathymic, bone marrow origin.

Journal

European Journal of ImmunologyWiley

Published: Jan 1, 1971

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