Bleeding score in Type 1 von Willebrand disease patients using the ISTH‐BAT questionnaire

Bleeding score in Type 1 von Willebrand disease patients using the ISTH‐BAT questionnaire INTRODUCTIONCareful history taking is the cornerstone in the approaches to diagnose von Willebrand disease (VWD) and is considered to be critical in assessing bleeding diathesis. Information about bleeding pattern, onset, and medical problems should be reviewed carefully to rule out acquired clinical conditions. Additionally, positive family history and compatible laboratory tests are required to consider the diagnosis.Type 1 VWD, is the most common bleeding disorder, defined by a quantitative deficiency of von Willebrand factor (VWF) and bleeding symptoms in a patient who also has family members with the same features. The International Society of Thrombosis and Hemostasis (ISTH) Scientific Subcommittee (SSC) developed and published provisional diagnostic criteria for VWD in 2005, which was approved at the 42nd Annual SSC Meeting in Barcelona. Accordingly, an asymptomatic person with low VWF must have a positive family history, which means that they must have at least 2 relatives with definite VWD type 1 and laboratory tests compatible with VWD type 1. The use of genetic tests, VWF mutations, or genetic markers linked to VWF locus, compatible with VWD may permit the analysis of more distant relatives and provide further evidence.Based on the ISTH/SSC criteria for laboratory tests, results are compatible with VWD http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Laboratory Hematology Wiley

Bleeding score in Type 1 von Willebrand disease patients using the ISTH‐BAT questionnaire

Loading next page...
 
/lp/wiley/bleeding-score-in-type-1-von-willebrand-disease-patients-using-the-PKKFyR1xp8
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 John Wiley & Sons Ltd
ISSN
1751-5521
eISSN
1751-553X
D.O.I.
10.1111/ijlh.12761
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONCareful history taking is the cornerstone in the approaches to diagnose von Willebrand disease (VWD) and is considered to be critical in assessing bleeding diathesis. Information about bleeding pattern, onset, and medical problems should be reviewed carefully to rule out acquired clinical conditions. Additionally, positive family history and compatible laboratory tests are required to consider the diagnosis.Type 1 VWD, is the most common bleeding disorder, defined by a quantitative deficiency of von Willebrand factor (VWF) and bleeding symptoms in a patient who also has family members with the same features. The International Society of Thrombosis and Hemostasis (ISTH) Scientific Subcommittee (SSC) developed and published provisional diagnostic criteria for VWD in 2005, which was approved at the 42nd Annual SSC Meeting in Barcelona. Accordingly, an asymptomatic person with low VWF must have a positive family history, which means that they must have at least 2 relatives with definite VWD type 1 and laboratory tests compatible with VWD type 1. The use of genetic tests, VWF mutations, or genetic markers linked to VWF locus, compatible with VWD may permit the analysis of more distant relatives and provide further evidence.Based on the ISTH/SSC criteria for laboratory tests, results are compatible with VWD

Journal

International Journal of Laboratory HematologyWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from
Google Scholar,
PubMed
Create lists to
organize your research
Export lists, citations
Read DeepDyve articles
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off