INTRODUCTIONCareful history taking is the cornerstone in the approaches to diagnose von Willebrand disease (VWD) and is considered to be critical in assessing bleeding diathesis. Information about bleeding pattern, onset, and medical problems should be reviewed carefully to rule out acquired clinical conditions. Additionally, positive family history and compatible laboratory tests are required to consider the diagnosis.Type 1 VWD, is the most common bleeding disorder, defined by a quantitative deficiency of von Willebrand factor (VWF) and bleeding symptoms in a patient who also has family members with the same features. The International Society of Thrombosis and Hemostasis (ISTH) Scientific Subcommittee (SSC) developed and published provisional diagnostic criteria for VWD in 2005, which was approved at the 42nd Annual SSC Meeting in Barcelona. Accordingly, an asymptomatic person with low VWF must have a positive family history, which means that they must have at least 2 relatives with definite VWD type 1 and laboratory tests compatible with VWD type 1. The use of genetic tests, VWF mutations, or genetic markers linked to VWF locus, compatible with VWD may permit the analysis of more distant relatives and provide further evidence.Based on the ISTH/SSC criteria for laboratory tests, results are compatible with VWD
International Journal of Laboratory Hematology – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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