Biomedical nanocomposites of poly(lactic acid) and calcium phosphate hybridized with modified carbon nanotubes for hard tissue implants

Biomedical nanocomposites of poly(lactic acid) and calcium phosphate hybridized with modified... Degradable polymer‐based materials are attractive in orthopedics and dentistry as an alternative to metallic implants for use as bone fixatives. Herein, a degradable polymer poly(lactic acid) (PLA) was combined with novel hybrid nanopowder of carbon nanotubes (CNTs)‐calcium phosphate (CP) for this application. In particular, CNTs‐CP hybrid nanopowders (0.1 and 0.25% CNTs) were prepared from the solution of ionically modified CNTs (mCNTs), which was specifically synthesized to be well‐dispersed and thus to effectively adsorb onto the CP nanoparticles. The mCNTs‐CP hybrid nanopowders were then mixed with PLA (up to 50%) to produce mCNTs‐CP‐PLA nanocomposites. The mechanical tensile strength of the nanocomposites was significantly improved by the addition of mCNTs‐CP hybrid nanopowders. Moreover, nanocomposites containing low concentration of mCNTs (0.1%) showed significantly stimulated biological responses including cell proliferation and osteoblastic differentiation in terms of gene and protein expressions. Based on this study, the addition of novel mCNT‐CP hybrid nanopowders to PLA biopolymer may be considered a new material choice for developing hard tissue implants. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Biomedical Materials Research Wiley

Biomedical nanocomposites of poly(lactic acid) and calcium phosphate hybridized with modified carbon nanotubes for hard tissue implants

Loading next page...
 
/lp/wiley/biomedical-nanocomposites-of-poly-lactic-acid-and-calcium-phosphate-81GeKmszs8
Publisher
Wiley
Copyright
Copyright © 2011 Wiley Subscription Services
ISSN
1552-4973
eISSN
1552-4981
D.O.I.
10.1002/jbm.b.31846
Publisher site
See Article on Publisher Site

Abstract

Degradable polymer‐based materials are attractive in orthopedics and dentistry as an alternative to metallic implants for use as bone fixatives. Herein, a degradable polymer poly(lactic acid) (PLA) was combined with novel hybrid nanopowder of carbon nanotubes (CNTs)‐calcium phosphate (CP) for this application. In particular, CNTs‐CP hybrid nanopowders (0.1 and 0.25% CNTs) were prepared from the solution of ionically modified CNTs (mCNTs), which was specifically synthesized to be well‐dispersed and thus to effectively adsorb onto the CP nanoparticles. The mCNTs‐CP hybrid nanopowders were then mixed with PLA (up to 50%) to produce mCNTs‐CP‐PLA nanocomposites. The mechanical tensile strength of the nanocomposites was significantly improved by the addition of mCNTs‐CP hybrid nanopowders. Moreover, nanocomposites containing low concentration of mCNTs (0.1%) showed significantly stimulated biological responses including cell proliferation and osteoblastic differentiation in terms of gene and protein expressions. Based on this study, the addition of novel mCNT‐CP hybrid nanopowders to PLA biopolymer may be considered a new material choice for developing hard tissue implants. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.

Journal

Journal of Biomedical Materials ResearchWiley

Published: Jan 1, 2011

Keywords: ; ; ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off