Bioactive Pimarane Diterpenes from the Arctic Fungus Eutypella sp. D‐1

Bioactive Pimarane Diterpenes from the Arctic Fungus Eutypella sp. D‐1 Two new pimarane diterpenes, libertellenone M (1) and libertellenone N (2), together with five known compounds were isolated from the culture extract of Eutypella sp. D‐1 derived from high‐latitude soil of the Arctic. The structures of these compounds were determined by spectroscopic data as well as experimental and calculated electronic circular dichroism (ECD) analysis. Antimicrobial and cytotoxic activities of the isolated compounds were evaluated. Compound 3 exhibited weak antibacterial activity against Escherichia coli, Bacillus subtilis, and Vibrio vulnificus, each with MIC values of 16 μg/mL. Compounds 2 and 3 showed moderate cytotoxic activity against K562 and MCF‐7 cell lines with IC50 values of 7.67 and 9.57 μm, respectively. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chemistry & Biodiversity Wiley

Bioactive Pimarane Diterpenes from the Arctic Fungus Eutypella sp. D‐1

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley‐VHCA AG, Zurich, Switzerland
ISSN
1612-1872
eISSN
1612-1880
D.O.I.
10.1002/cbdv.201700501
Publisher site
See Article on Publisher Site

Abstract

Two new pimarane diterpenes, libertellenone M (1) and libertellenone N (2), together with five known compounds were isolated from the culture extract of Eutypella sp. D‐1 derived from high‐latitude soil of the Arctic. The structures of these compounds were determined by spectroscopic data as well as experimental and calculated electronic circular dichroism (ECD) analysis. Antimicrobial and cytotoxic activities of the isolated compounds were evaluated. Compound 3 exhibited weak antibacterial activity against Escherichia coli, Bacillus subtilis, and Vibrio vulnificus, each with MIC values of 16 μg/mL. Compounds 2 and 3 showed moderate cytotoxic activity against K562 and MCF‐7 cell lines with IC50 values of 7.67 and 9.57 μm, respectively.

Journal

Chemistry & BiodiversityWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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