Behavioral indices of moderate nigro‐striatal 6‐hydroxydopamine lesion: A preclinical Parkinson's model

Behavioral indices of moderate nigro‐striatal 6‐hydroxydopamine lesion: A preclinical... Asymmetries in turning and scanning were investigated in rats with different degrees of neostriatal dopamine depletion after unilateral injections of 6‐hydroxydopamine into the substantia nigra. Animals with severe lesions, i. e., residual dopamine levels of <20%, spontaneously turned ipsiversive and showed more scanning behavior with the side ipsilateral to the lesion. These asymmetries were reversed by the dopamine receptor agonist apomorphine. Animals with less severe dopamine depletion, i. e., residual dopamine levels of 20–65%, did not show an asymmetry in spontaneous turning, but an ipsilateral asymmetry in scanning was still observed, indicating a greater sensitivity of this measure for moderate striatal dopamine depletions. Furthermore, in animals with residual dopamine levels of 45–65%, the dopamine receptor agonist apomorphine did not lead to a behavioral reversal as with severe lesions, but induced ipsilateral scanning and ipsiversive turning. These ipsiversive asymmetries are discussed in relation to asymmetries in self‐regulatory mechanisms of the nigro‐striatal dopamine system, such as dopamine autoreceptors controlling the release of this transmitter. Dopamine receptor‐stimulated behavioral asymmetry in animals with moderate depletions of dopamine is suggested as a preclinical model to study mechanisms affected in the early state of Parkinson's disease. © 1993 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Synapse Wiley

Behavioral indices of moderate nigro‐striatal 6‐hydroxydopamine lesion: A preclinical Parkinson's model

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Publisher
Wiley
Copyright
Copyright © 1993 Wiley‐Liss, Inc.
ISSN
0887-4476
eISSN
1098-2396
D.O.I.
10.1002/syn.890130209
Publisher site
See Article on Publisher Site

Abstract

Asymmetries in turning and scanning were investigated in rats with different degrees of neostriatal dopamine depletion after unilateral injections of 6‐hydroxydopamine into the substantia nigra. Animals with severe lesions, i. e., residual dopamine levels of <20%, spontaneously turned ipsiversive and showed more scanning behavior with the side ipsilateral to the lesion. These asymmetries were reversed by the dopamine receptor agonist apomorphine. Animals with less severe dopamine depletion, i. e., residual dopamine levels of 20–65%, did not show an asymmetry in spontaneous turning, but an ipsilateral asymmetry in scanning was still observed, indicating a greater sensitivity of this measure for moderate striatal dopamine depletions. Furthermore, in animals with residual dopamine levels of 45–65%, the dopamine receptor agonist apomorphine did not lead to a behavioral reversal as with severe lesions, but induced ipsilateral scanning and ipsiversive turning. These ipsiversive asymmetries are discussed in relation to asymmetries in self‐regulatory mechanisms of the nigro‐striatal dopamine system, such as dopamine autoreceptors controlling the release of this transmitter. Dopamine receptor‐stimulated behavioral asymmetry in animals with moderate depletions of dopamine is suggested as a preclinical model to study mechanisms affected in the early state of Parkinson's disease. © 1993 Wiley‐Liss, Inc.

Journal

SynapseWiley

Published: Feb 1, 1993

References

  • Time course of adaptations in dopamine biosynthesis, metabolism, and release following nigrostriatal lesions: Implications for behavioral recovery from brain injury
    Altar, Altar; Marien, Marien; Marshall, Marshall
  • Evidence for a receptor‐mediated feedback control of tyrosine hydroxylase activity
    Kehr, Kehr; Carlsson, Carlsson; Lindqvist, Lindqvist; Magnusson, Magnusson; Atack, Atack
  • Effects of apomorphine on in vivo release of dopamine and its metabolites in the prefrontal cortex and the striatum, studied by a microdialysis method
    Ozaki, Ozaki; Nakahara, Nakahara; Miura, Miura; Kasahara, Kasahara; Nagatsu, Nagatsu
  • Partial dopamine depletions result in an enhanced sensitivity of residual dopamine neurons to apomorphine
    Pucak, Pucak; Grace, Grace
  • Dopamine and serotonin metabolism in brain sites ipsi‐ and contralateral to direction of conditioned turning in rats
    Schwarting, Schwarting; Huston, Huston
  • D1 dopamine receptor stimulation enables the postsynaptic, but not autoreceptor, effects of D2 dopamine agonists in nigrostriatal and mesoaccumbens dopamine systems
    Wachtel, Wachtel; Hu, Hu; Galloway, Galloway; White, White

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