Universitatshautklinik, v. Siebold-Strasse 3, D-3400 GOttingen, W. Germany The starting point for the following explanations are findings (Ippen & Montag, 1958; Ippen, 1959a; 1959b) which I noted during the years 1956-1958, together with those of Doring-Petersen (1958), Goerz Ci959)> Montag (1958), Lehmann (1965), Franz (1977) and Franz & Ippen (1976). METABOLISM OH 0 OH Oxidotion Reduction OH Anihrolin Oanfhrone After topical application, anthralin (Dithranol (WHO) trade marks: Cignolin, Psoriacide, etc.) is oxidized in the skin to 'Cignolin-Braun' and to the quinone danthrone. After this oxidation, danthrone (Chrysacin, trade marks: Dorbanex, Istizin, Modane, Regulin, etc.) is excreted in the urine. After oral ingestion as a cathartic, danthrone is reduced to anthralin in the large bowel. After this reduction anthralin is excreted with the faeces. In the upper gastro-intestinal tract danthrone is partially absorbed and excreted with the urine. The formation of anthralin from danthrone in the colon can additionally be shown by the so called 'Istizin-exanthema' due to perianal anthralin irritation (Ippen, 1959c; 1975). Finally, the melanosis coli, after the abuse of anthraquinone cathartics, is concerned with a process which fully corresponds to the formation of 'Cignolin-Braun' in the skin: during the oxidation of anthralin in the upper epidermis
British Journal of Dermatology – Wiley
Published: Aug 1, 1981
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