P159 Cerebrovascular status and Type 1 diabetes durationID Wilkinson1, F Fang2, M Greig1, L HUNT1, S Pallai3, S Tesfaye4, D Selvarajah31Academic Radiology, University of Sheffield, Sheffield, UK, 2Endocrinology, Shanghai JiaoTong University, Shanghai, China, 3Oncology and Metabolism, University of Sheffield, Sheffield, UK, 4Diabetes, Sheffield Teaching Hospitals, Sheffield, UKObjectives: Cerebral small vessel disease (SVD) is a complication in Type 1 diabetes. Magnetic resonance imaging (MRI) can monitor the presence and consequences of SVD. This study investigates internal carotid artery (ICA), flow resistivity index (RI) and standard imaging appearances as a function of Type 1 diabetes duration.Methods: Sixty‐six subjects (49 Type 1 diabetes and 17 healthy volunteers, HVs) with no history of cardiovascular disease/stroke were assessed and grouped by diabetes duration [short ≤15 years, medium = 15 to 30 years; long ≥30 years]. Lacunes, white matter hyperintensities (WMH) and atrophy were rated on T2‐weighted MRI. Quantitative magnetic resonance angiography assessed carotid RI.Results: There were significant differences in group mean ICA RI (HV = 0.54 ± 0.05, short = 0.56 ± 0.08, medium = 0.63 ± 0.06, long term = 0.65 ± 0.06; p < 0.001). Post hoc analysis indicated higher RI in long‐ and medium‐term compared with both short‐term (p < 0.005; p < 0.05) and HV (p < 0.001; p < 0.001) groups. There were no significant group differences in the prevalence of imaging abnormalities (χ2 = 7.064, p > 0.05). In cases of no imaging
Diabetic Medicine – Wiley
Published: Jan 1, 2018
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