P130 Diabetes Remission Clinical Trial (DiRECT): Early effects of weight loss on liver fat and fasting plasma insulin in Type 2 diabetes of less than six‐year durationSV ZHYZHNEUSKAYA1, A Al‐Mrabeh1, C Peters1, A Barnes2, H Pilkington3, KG Holligsworth1, MEJ Lean4, R Taylor11Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK, 2Human Nutrition Research Centre, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK, 3Clinical Ageing Research Unit, Newcastle University, Campus for ageing and Vitality, Newcastle upon Tyne, UK, 4School of Medicine, Dentistry and Nursing, University of Glasgow, Royal Infirmary, Glasgow, UKRefer to Oral number A16P131 Acute metabolic effects of activation of GPR120 with selective long‐chain fatty acid agonists on islet and enteroendocrine cell functionAG MCCLOSKEY, MG Miskelly, PR Flatt, AM McKillopSchool of Biomedical Sciences, Ulster University, Coleraine, UKAims: Free fatty acid receptor 4 (GPR120) is a potential anti‐diabetic target, through the regulation of islet/enteroendocrine cell function. Selective agonists were utilised to investigate the regulatory role of GPR120 in glucose homeostasis.Methods: Specificity and insulinotropic properties of GPR120 agonists were evaluated in rodent (BRIN‐BD11) and human (1.1B4) cell lines. GPR120 expression and distribution were assessed by qPCR and western blotting in BRIN‐BD11 cells and by
Diabetic Medicine – Wiley
Published: Jan 1, 2018
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