P118The utility of urinary c‐peptide creatinine ratio to assess insulin sensitivity in pregnancyLC MENDOZA, V Sonagara, J Chang, A Markoska, R Valaiyapathi, C Thorn, A DornhorstMedicine, Hammersmith Hospital, Imperial College of London, London, UKAims: There is a hyperbolic relationship between insulin sensitivity and insulin secretion. In pregnancy, gestational diabetes (GDM) occurs when insulin secretion fails to compensate for the physiological decrease in insulin sensitivity (IS). Urinary c‐peptide creatinine ratio (UCPCR) measures endogenous insulin secretion. UCPCR unlike serum insulin and c‐peptide requires no immediate laboratory handling. In pregnancy, UCPCR values during a 75‐g OGTT correlates with serum c‐peptide at 0 and 120min. A modified Matsuda equation using serum c‐peptide in place of serum insulin provides a validated measure of IS in pregnancy. The current study evaluates a further modification to the Matsuda equation using UCPCR during a 75‐g OGTT (ISOGTT UCPCR).Methods: A 75‐g OGTT was performed on 80 women at around 28 weeks’ gestation. Urine samples were collected at 0 and 120min. Urinary c‐peptide was measured using a chemiluminescent immunoassay. The two UCPCR values replaced c‐peptide in the Radaelli‐Matsuda equation. A disposition index was calculated as the product of ISOGTT UCPCR and the 120min UCPCR.Results: Seventy‐three women had normal glucose tolerance and
Diabetic Medicine – Wiley
Published: Jan 1, 2018
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