P87 Carrying more ‘favourable adiposity’ genetic factors is associated with higher adiposity but lower ectopic fat and lower risk of Type 2 diabetesH YAGHOOTKAR1, Y Ji1, AM Yiorkas2,3, J Tyrrell1, SE Jones1, R Beaumont1, AR Wood1, AIF Blakemore2,3, JD Bell4, TM Frayling11Genetics of Human Complex Traits, University of Exeter Medical School, Exeter, UK, 2Section of Investigative Medicine, Imperial College London, London, UK, 3Department of Life Sciences, Brunel University London, Uxbridge, UK, 4Research Centre for Optimal Health, University of Westminster, London, UKRefer to Oral number A59P88An improved genetic risk score to identify and discriminate Type 1 diabetesSA SHARP1, MN Weedon1, AT Hattersley1, W Hagopian2, RA Oram11University of Exeter Medical School, University of Exeter, Exeter, UK, 2The Pacific Northwest Research Institute, Seattle, USAAim: A Type 1 diabetes genetic risk score (T1D‐GRS) is a simple, inexpensive test that improves discrimination of Type 1 diabetes from other forms of diabetes and has both clinical and research utility. We aimed to maximise the discriminative power of a T1D‐GRS by improved capture of genetic variants.Methods: We used genetic data from 15,731 White (6,484 Type 1 diabetes) in the Type 1 Diabetes Genetics Consortium (T1DGC) to look for variants marking 26 additional HLA haplogenotypes. We looked for
Diabetic Medicine – Wiley
Published: Jan 1, 2018
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