P51Retinal arterial tortuosity is a novel biomarker associated with incident stroke in people with Type 2 diabetes: The Edinburgh Type 2 diabetes Study (ET2DS)E SANDOVAL1, S McLachlan1, M Strachan2, T MacGillivray3, JF Wilson1, J Price11Usher Institute, Centre for Population and Health Sciences, The University of Edinburgh, Edinburgh, UK, 2Metabolic Unit, Western General Hospital, NHS Lothian, Edinburgh, UK, 3Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UKRefer to Oral number A80P52 Impaired hypoxia‐inducible factor (HIF) 1α signalling in Type 2 diabetes following myocardial infarction is due to increased fatty acids, and can be reversed pharmacologically to improve post‐ischaemic recoveryMDL SOUSA FIALHO1, M Dodd1, C Montes Aparicio1, M Kerr1, K Timm1, J Griffin2, D Tyler1, L Heather11Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK, 2Department of Biochemistry, University of Cambridge, Cambridge, UKAims: HIF1α is activated following myocardial infarction and is critical for cell survival post‐ischaemia. Patients with diabetes progress into heart failure more rapidly than patients without diabetes. We questioned whether HIF1α activation post‐ischaemia was abnormal in Type 2 diabetes, what the mechanism behind this was, and whether this could be reversed pharmacologically to improve the function of the heart in Type 2 diabetes.Methods/ResultsType 2 diabetic
Diabetic Medicine – Wiley
Published: Jan 1, 2018
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