Bacterial aetiology of recalcitrant acute otitis media in 62 children—high risk of pathogen colonisation after treatment

Bacterial aetiology of recalcitrant acute otitis media in 62 children—high risk of pathogen... KeypointsPositive pathogen colonisation in 70% of (AOM) patients with acute otitis media, including Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis after standard antibiotic therapy could be associated with a high possibility of AOM recurrence.High frequency of penicillin non‐susceptible S. pneumoniae isolates in children with recalcitrant AOM was observed. During post‐treatment control visits, penicillin non‐susceptible strains constituted 100% of isolated pneumococci. Prevalence of β‐lactamase‐positive H. influenzae strains increased to 64.7% of isolates comparing to 56% isolated in AOM.There was correspondence between the pathogen species isolated during AOM and during control visit after treatment in about 49% patients. S. pneumoniae‐positive culture from nasopharyngeal samples may provide an accurate proxy for the positive MEF culture when MEF samples cannot be obtained.Older children, not attending day care institutions with shorter time of antibiotic therapy, were at risk of recalcitrant AOM. Moreover, risk of pathogen colonisation after treatment was associated with younger age, and bilateral ear infection in the studied children.Nasopharyngeal pneumococcal colonisation rates were significantly higher than oropharyngeal and contrary to H. influenzae colonisation which was found significantly higher in oropharyngeal samples.BACKGROUNDAcute otitis media (AOM), common childhood infection that is one of the leading causes of antibiotic prescriptions for children, is diagnosed at least http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Otolaryngology Wiley

Bacterial aetiology of recalcitrant acute otitis media in 62 children—high risk of pathogen colonisation after treatment

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 John Wiley & Sons Ltd
ISSN
1749-4478
eISSN
1749-4486
D.O.I.
10.1111/coa.12986
Publisher site
See Article on Publisher Site

Abstract

KeypointsPositive pathogen colonisation in 70% of (AOM) patients with acute otitis media, including Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis after standard antibiotic therapy could be associated with a high possibility of AOM recurrence.High frequency of penicillin non‐susceptible S. pneumoniae isolates in children with recalcitrant AOM was observed. During post‐treatment control visits, penicillin non‐susceptible strains constituted 100% of isolated pneumococci. Prevalence of β‐lactamase‐positive H. influenzae strains increased to 64.7% of isolates comparing to 56% isolated in AOM.There was correspondence between the pathogen species isolated during AOM and during control visit after treatment in about 49% patients. S. pneumoniae‐positive culture from nasopharyngeal samples may provide an accurate proxy for the positive MEF culture when MEF samples cannot be obtained.Older children, not attending day care institutions with shorter time of antibiotic therapy, were at risk of recalcitrant AOM. Moreover, risk of pathogen colonisation after treatment was associated with younger age, and bilateral ear infection in the studied children.Nasopharyngeal pneumococcal colonisation rates were significantly higher than oropharyngeal and contrary to H. influenzae colonisation which was found significantly higher in oropharyngeal samples.BACKGROUNDAcute otitis media (AOM), common childhood infection that is one of the leading causes of antibiotic prescriptions for children, is diagnosed at least

Journal

Clinical OtolaryngologyWiley

Published: Jan 1, 2018

References

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