Autologous peripheral blood progenitor cells are a potential source of parvovirus B19 infection

Autologous peripheral blood progenitor cells are a potential source of parvovirus B19 infection BACKGROUND: Parvovirus B19 is a cause of delayed red blood cell (RBC) engraftment after marrow transplantation (BMT). The diagnosis of parvovirus infection requires serologic and DNA testing in the context of clinical disease and characteristic marrow morphologic findings; however, the source of infection is often difficult to determine. STUDY DESIGN AND METHODS: Investigation of a case of delayed RBC engraftment and pure RBC aplasia (PRCA) occurring 3 months after autologous peripheral blood progenitor cell (PBPC) transplantation in a patient with high‐risk diffuse large B‐cell lymphoma. DNA testing of serum and of a sample of cryopreserved PBPCs was performed. RESULTS: Marrow morphology showed a maturational arrest of erythroid cells with giant proerythroblasts. Polymerase chain reaction and nucleic acid hybridization confirmed the presence of parvovirus DNA in the serum and in a sample of sequestered PBPCs saved at the time of PBPC harvest. PRCA resolved after the administration of intravenous immune globulin. CONCLUSION: Autologous PBPCs are a potential source of parvovirus infection, which may cause significant disease after autologous BMT. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Transfusion Wiley

Autologous peripheral blood progenitor cells are a potential source of parvovirus B19 infection

Loading next page...
 
/lp/wiley/autologous-peripheral-blood-progenitor-cells-are-a-potential-source-of-9WQd5kRQ7Z
Publisher
Wiley
Copyright
Copyright © 2005 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0041-1132
eISSN
1537-2995
DOI
10.1111/j.1537-2995.2005.04267.x
Publisher site
See Article on Publisher Site

Abstract

BACKGROUND: Parvovirus B19 is a cause of delayed red blood cell (RBC) engraftment after marrow transplantation (BMT). The diagnosis of parvovirus infection requires serologic and DNA testing in the context of clinical disease and characteristic marrow morphologic findings; however, the source of infection is often difficult to determine. STUDY DESIGN AND METHODS: Investigation of a case of delayed RBC engraftment and pure RBC aplasia (PRCA) occurring 3 months after autologous peripheral blood progenitor cell (PBPC) transplantation in a patient with high‐risk diffuse large B‐cell lymphoma. DNA testing of serum and of a sample of cryopreserved PBPCs was performed. RESULTS: Marrow morphology showed a maturational arrest of erythroid cells with giant proerythroblasts. Polymerase chain reaction and nucleic acid hybridization confirmed the presence of parvovirus DNA in the serum and in a sample of sequestered PBPCs saved at the time of PBPC harvest. PRCA resolved after the administration of intravenous immune globulin. CONCLUSION: Autologous PBPCs are a potential source of parvovirus infection, which may cause significant disease after autologous BMT.

Journal

TransfusionWiley

Published: Mar 1, 2005

References

  • Human parvovirus B19 infection in bone marrow transplantation patients
    Azzi, Azzi; Fanci, Fanci; Ciappi, Ciappi; Zakrzewska, Zakrzewska; Bosi, Bosi
  • Transfusion‐transmitted human parvovirus B19 infection in a thalassemic patient
    Zanella, Zanella; Rossi, Rossi; Cesana, Cesana
  • Chronic anemia due to parvovirus B19 infection in a bone marrow transplant patient after platelet transfusion
    Cohen, Cohen; Beard, Beard; Knowles, Knowles
  • Quantitative real‐time detection of parvovirus B19 DNA in plasma
    Koppelman, Koppelman; Cuypers, Cuypers; Emrich, Emrich; Zaaijer, Zaaijer
  • NAT screening of blood and plasma donations. evolution of technology and regulatory policy
    Tabor, Tabor; Epstein, Epstein

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off