Atypical fibroxanthoma with prominent CD8‐positive lymphocytic infiltration and diffuse expression of epithelial membrane antigen

Atypical fibroxanthoma with prominent CD8‐positive lymphocytic infiltration and diffuse... Correspondence Clinical Letter AFX [4–6]. However, AFX lesions accompanied by diffuse Clinical Letter infiltration of immune cells have rarely been reported. Her - Atypical fibroxanthoma with prominent CD8- ein, we report a case of AFX with prominent infiltration of CD8-positive lymphocytes. Immunohistochemical analysis positive lymphocytic infiltration and diffuse revealed the tumor cells to diffusely express epithelial mem- expression of epithelial membrane antigen brane antigen (EMA), an extremely rare finding. A 74-year-old Japanese woman presented with a two- month history of a rapidly growing, reddish, dome-shaped, DOI: 10.1111/ddg.13406 ulcerated tumor (20 mm in diameter) on her right temple (Figure 1a). Dermatoscopic examination revealed a homoge- Dear Editors, neous red pattern with linear vessels (Figure 1b). Histopatho- logically, the exophytic tumor was characterized by a highly Atypical fibroxanthoma (AFX) is a rare, rapidly growing tu - cellular dermal mass (Figure 1c). The overlying epidermis mor of intermediate malignancy that develops on the sun-ex- was almost completely ulcerated, except for a peripheral epi- posed skin of elderly individuals. Clinically, it usually presents dermal collarette. The tumor was made up of atypical spindle as a solitary, firm, reddish papule or nodule [1, 2]. Histopa - and epithelioid cells with pleomorphic nuclei (Figure 1d). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal Der Deutschen Dermatologischen Gesellschaft Wiley

Atypical fibroxanthoma with prominent CD8‐positive lymphocytic infiltration and diffuse expression of epithelial membrane antigen