Astroglia in CNS injury

Astroglia in CNS injury The astroglial response to CNS injury is considered in the context of neuron‐glial relationships. Although previous models suggested that astroglial cells present in “scars” impede axon regrowth owing to irreversible changes in the glial cell following injury, recent in vivo and in vitro studies indicate that astroglial cells exhibit considerable plasticity, elevating expression of the glial filament protein and altering expression of properties which support axons, including extracellular matrix components and cell surface adhesion systems. Both in vivo and in vitro studies on neuron‐glia interactions in different brain regions suggest that glia express region‐specific properties, including ion channels, neurotransmitter uptake and receptor systems, and cell surface adhesion systems. Together these findings suggest that a more detailed analysis of glial response to injury in different brain regions will lead to an appreciation of the diversity of the astroglial response to injury, and its regulation by neuron‐glia relationships. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Glia Wiley

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Publisher
Wiley
Copyright
Copyright © 1991 Wiley‐Liss, Inc.
ISSN
0894-1491
eISSN
1098-1136
DOI
10.1002/glia.440040215
Publisher site
See Article on Publisher Site

Abstract

The astroglial response to CNS injury is considered in the context of neuron‐glial relationships. Although previous models suggested that astroglial cells present in “scars” impede axon regrowth owing to irreversible changes in the glial cell following injury, recent in vivo and in vitro studies indicate that astroglial cells exhibit considerable plasticity, elevating expression of the glial filament protein and altering expression of properties which support axons, including extracellular matrix components and cell surface adhesion systems. Both in vivo and in vitro studies on neuron‐glia interactions in different brain regions suggest that glia express region‐specific properties, including ion channels, neurotransmitter uptake and receptor systems, and cell surface adhesion systems. Together these findings suggest that a more detailed analysis of glial response to injury in different brain regions will lead to an appreciation of the diversity of the astroglial response to injury, and its regulation by neuron‐glia relationships.

Journal

GliaWiley

Published: Jan 1, 1991

References

  • Growth of adult rat retinal ganglion cell neurites on astrocytes
    Baehr, Baehr; Bunge, Bunge
  • Ion channel expression by white matter glia. I. Type 2 astrocytes and oligodendrocytes
    Barres, Barres; Chun, Chun; Corey, Corey

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