Associations of oral fluid MMP‐8 with periodontitis in Swiss adult subjects

Associations of oral fluid MMP‐8 with periodontitis in Swiss adult subjects INTRODUCTIONPeriodontitis is a slowly progressing chronic polymicrobial infection‐induced inflammation. Under inflammatory conditions, endogenous degradation pathways are activated and immune response leads to the release of destructive cellular molecules, that is proteases and reactive oxygen species as well as cytokines and chemokines (Kinane, Preshaw, & Loos, ; Sapna, Gokul, & Bagri‐Manjrekar, ). Consequently, periodontitis has been shown to be associated with susceptibility to certain systemic diseases including diabetes, cardiovascular diseases and stroke (Alfakry, Malle, Koyani, Pussinen, & Sorsa, ; Lauhio et al., ; Lockhart et al., ; Noack et al., ; Palm et al., ).Despite increasing evidence of potential links between the periodontal inflammatory burden and systemic health, diagnoses still rely on invasive clinical measurements and radiographic assessments. These methods are expensive, requiring dental professionals and detecting the disease only in advanced states. Thus, discovering a biomarker with improved diagnostic capability and ease of use is of paramount importance.Matrix metalloproteinases (MMPs) have an important role in periodontitis via degrading extracellular matrix components (Sorsa, Gieselmann, Arweiler, & Hernandez, ; Sorsa, Tjäderhane, & Salo, ; Sorsa, Heikkinen et al., ). Particularly, elevated levels of active neutrophil collagenase, MMP‐8, have been shown to be associated with chronic periodontitis and accelerated disease progression (Ingman et al., ; Kinney et al., ; http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Oral Diseases Wiley

Associations of oral fluid MMP‐8 with periodontitis in Swiss adult subjects

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley &Sons Ltd
ISSN
1354-523X
eISSN
1601-0825
D.O.I.
10.1111/odi.12769
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONPeriodontitis is a slowly progressing chronic polymicrobial infection‐induced inflammation. Under inflammatory conditions, endogenous degradation pathways are activated and immune response leads to the release of destructive cellular molecules, that is proteases and reactive oxygen species as well as cytokines and chemokines (Kinane, Preshaw, & Loos, ; Sapna, Gokul, & Bagri‐Manjrekar, ). Consequently, periodontitis has been shown to be associated with susceptibility to certain systemic diseases including diabetes, cardiovascular diseases and stroke (Alfakry, Malle, Koyani, Pussinen, & Sorsa, ; Lauhio et al., ; Lockhart et al., ; Noack et al., ; Palm et al., ).Despite increasing evidence of potential links between the periodontal inflammatory burden and systemic health, diagnoses still rely on invasive clinical measurements and radiographic assessments. These methods are expensive, requiring dental professionals and detecting the disease only in advanced states. Thus, discovering a biomarker with improved diagnostic capability and ease of use is of paramount importance.Matrix metalloproteinases (MMPs) have an important role in periodontitis via degrading extracellular matrix components (Sorsa, Gieselmann, Arweiler, & Hernandez, ; Sorsa, Tjäderhane, & Salo, ; Sorsa, Heikkinen et al., ). Particularly, elevated levels of active neutrophil collagenase, MMP‐8, have been shown to be associated with chronic periodontitis and accelerated disease progression (Ingman et al., ; Kinney et al., ;

Journal

Oral DiseasesWiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ;

References

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