Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder

Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major... There is evidence indicating that density of 5‐HT2A receptors is altered in brain regions of depressed suicide victims and in platelets of suicidal subjects with major depression or schizophrenia. Recent studies have also shown an association between the allele C of 102T/C polymorphism in the 5‐HT2A receptor gene and schizophrenia. The present investigation tested the hypothesis that the observed changes in 5‐HT2A receptor density in platelets of patients with major depression are a trait rather than state phenomenon and are associated with the 102 C allele in 5‐HT2A receptor gene in a sample of 120 patients with major depression and a group of 131 control subjects comparable with respect to age, sex, and ethnic background. The allele and genotype frequencies of 102T/C polymorphism in 5‐HT2A receptor gene were compared between patients and control subjects and between suicidal and non‐suicidal patient groups. The major finding of this study was a significant association between the 102 C allele in 5‐HT2A receptor gene and major depression, χ2 = 4.5, df = 1, P = 0.03, particularly in patients with suicidal ideation, χ2 = 8.5, df = 1, P < 0.005. Furthermore, we found that patients with a 102 C/C genotype had a significantly higher mean HAMD item 3 score (indication of suicidal ideation) than T/C or T/T genotype patients. Our results suggest that the 102T/C polymorphism in 5‐HT2A receptor gene is primarily associated with suicidal ideation in patients with major depression. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:56–60, 2000. © 2000 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Medical Genetics Wiley

Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder

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Publisher
Wiley
Copyright
Copyright © 2000 Wiley‐Liss, Inc.
ISSN
0148-7299
eISSN
1096-8628
DOI
10.1002/(SICI)1096-8628(20000207)96:1<56::AID-AJMG12>3.3.CO;2-C
Publisher site
See Article on Publisher Site

Abstract

There is evidence indicating that density of 5‐HT2A receptors is altered in brain regions of depressed suicide victims and in platelets of suicidal subjects with major depression or schizophrenia. Recent studies have also shown an association between the allele C of 102T/C polymorphism in the 5‐HT2A receptor gene and schizophrenia. The present investigation tested the hypothesis that the observed changes in 5‐HT2A receptor density in platelets of patients with major depression are a trait rather than state phenomenon and are associated with the 102 C allele in 5‐HT2A receptor gene in a sample of 120 patients with major depression and a group of 131 control subjects comparable with respect to age, sex, and ethnic background. The allele and genotype frequencies of 102T/C polymorphism in 5‐HT2A receptor gene were compared between patients and control subjects and between suicidal and non‐suicidal patient groups. The major finding of this study was a significant association between the 102 C allele in 5‐HT2A receptor gene and major depression, χ2 = 4.5, df = 1, P = 0.03, particularly in patients with suicidal ideation, χ2 = 8.5, df = 1, P < 0.005. Furthermore, we found that patients with a 102 C/C genotype had a significantly higher mean HAMD item 3 score (indication of suicidal ideation) than T/C or T/T genotype patients. Our results suggest that the 102T/C polymorphism in 5‐HT2A receptor gene is primarily associated with suicidal ideation in patients with major depression. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:56–60, 2000. © 2000 Wiley‐Liss, Inc.

Journal

American Journal of Medical GeneticsWiley

Published: Feb 7, 2000

Keywords: suicidal ideation; serotonin; 5‐HT2A receptor gene; major depression

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