Association of p16 (CDKN2A) polymorphisms with the development of HPV16‐related precancerous lesions and cervical cancer in the Greek population

Association of p16 (CDKN2A) polymorphisms with the development of HPV16‐related precancerous... INTRODUCTIONHuman papillomaviruses (HPVs) consist of a heterogeneous group of non‐enveloped, capsid‐enclosed dsDNA viruses, 55 nm in diameter that exhibit a different tropism for mucosal or cutaneous epithelia. Today more than 170 HPV genotypes have been completely characterized with each one of them displaying different life cycle features and carcinogenic properties. A phylogenetic tree based on the L1 gene clustered the different HPV genotypes into five genera—alpha, beta, gamma, mu, and nu. The Alphapapillomaviruses can be further sub‐divided into high‐risk (HR) genotypes and low‐risk (LR) genotypes considering their epidemiological association with neoplastic disease. Persistent infection with high‐risk HPV genotypes is regarded as the most crucial risk factor for cervical cancer development. Cancer of the uterine cervix is the third most common malignancy in women in terms of incidence and mortality rates and it is the second leading cause of cancer‐associated deaths, worldwide, with higher frequency in low‐income countries. Global epidemiological investigations have indicated that HPV16 and HPV18 are the most tumorigenic genotypes and they are responsible for approximately 50% and 20% of cervical cancer cases, respectively.The high expression level of high‐risk E6 and E7 oncoproteins is the biological hallmark for initiation of neoplastic disease, since they target and inactivate the cell‐cycle http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Virology Wiley

Association of p16 (CDKN2A) polymorphisms with the development of HPV16‐related precancerous lesions and cervical cancer in the Greek population

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0146-6615
eISSN
1096-9071
D.O.I.
10.1002/jmv.24996
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONHuman papillomaviruses (HPVs) consist of a heterogeneous group of non‐enveloped, capsid‐enclosed dsDNA viruses, 55 nm in diameter that exhibit a different tropism for mucosal or cutaneous epithelia. Today more than 170 HPV genotypes have been completely characterized with each one of them displaying different life cycle features and carcinogenic properties. A phylogenetic tree based on the L1 gene clustered the different HPV genotypes into five genera—alpha, beta, gamma, mu, and nu. The Alphapapillomaviruses can be further sub‐divided into high‐risk (HR) genotypes and low‐risk (LR) genotypes considering their epidemiological association with neoplastic disease. Persistent infection with high‐risk HPV genotypes is regarded as the most crucial risk factor for cervical cancer development. Cancer of the uterine cervix is the third most common malignancy in women in terms of incidence and mortality rates and it is the second leading cause of cancer‐associated deaths, worldwide, with higher frequency in low‐income countries. Global epidemiological investigations have indicated that HPV16 and HPV18 are the most tumorigenic genotypes and they are responsible for approximately 50% and 20% of cervical cancer cases, respectively.The high expression level of high‐risk E6 and E7 oncoproteins is the biological hallmark for initiation of neoplastic disease, since they target and inactivate the cell‐cycle

Journal

Journal of Medical VirologyWiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ;

References

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