Access the full text.
Sign up today, get DeepDyve free for 14 days.
Feng-hai Wu, Yong Huang, Fengshi Dong, J. Kwon (2016)
Ulcerative Colitis-Associated Long Noncoding RNA, BC012900, Regulates Intestinal Epithelial Cell ApoptosisInflammatory Bowel Diseases, 22
E. Hungate, Sapana Vora, E. Gamazon, Takaya Moriyama, T. Best, Imge Hulur, Younghee Lee, T. Evans, E. Ellinghaus, M. Stanulla, J. Rudant, L. Orsi, J. Clavel, E. Milne, R. Scott, C. Pui, N. Cox, M. Loh, Jun Yang, Andrew Skol, K. Onel (2016)
A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiologyNature Communications, 7
Hailiang Huang, M. Fang, L. Jostins, Masa Mirkov, G. Boucher, C. Anderson, V. Andersen, I. Cleynen, A. Cortes, François Crins, M. D’Amato, V. Deffontaine, Julia Dmitrieva, E. Docampo, Mahmoud Elansary, K. Farh, A. Franke, A. Gori, P. Goyette, J. Halfvarson, T. Haritunians, J. Knight, I. Lawrance, C. Lees, E. Louis, R. Mariman, T. Meuwissen, M. Mni, Y. Momozawa, M. Parkes, S. Spain, E. Théâtre, G. Trynka, J. Satsangi, S. Sommeren, S. Vermeire, R. Xavier, R. Weersma, R. Duerr, C. Mathew, J. Rioux, D. McGovern, Judy Cho, M. Georges, M. Daly, J. Barrett (2017)
Fine-mapping inflammatory bowel disease loci to single variant resolutionNature, 547
B. Ye, Hyunchul Choi, Myunghee Hong, W. Yun, H. Low, T. Haritunians, Kyung-Jo Kim, S. Park, Inchul Lee, S. Bang, Tae-Hwan Kim, H. Shin, D. Kang, H. Youn, Yi Li, Jianjun Liu, D. McGovern, Suk-Kyun Yang, K. Song (2016)
Identification of Ten Additional Susceptibility Loci for Ulcerative Colitis Through Immunochip Analysis in KoreansInflammatory Bowel Diseases, 22
A. Boyle, Eurie Hong, M. Hariharan, Yong Cheng, M. Schaub, Maya Kasowski, K. Karczewski, Julie Park, B. Hitz, S. Weng, J. Cherry, M. Snyder (2012)
Annotation of functional variation in personal genomes using RegulomeDBGenome Research, 22
S. Park, Suk-Kyun Yang, Soo-Kyung Park, Jong Kim, Dong-Hoon Yang, K. Jung, Kyung-Jo Kim, B. Ye, J. Byeon, S. Myung, Y. Yoon, Chang Yu, Jin-Ho Kim (2014)
Long-term Prognosis of Crohn's Disease and Its Temporal Change Between 1981 and 2012: A Hospital-based Cohort Study from KoreaInflammatory Bowel Diseases, 20
G. Bignell, C. Greenman, H. Davies, Adam Butler, S. Edkins, J. Andrews, G. Buck, Lina Chen, D. Beare, Calli Latimer, S. Widaa, Jonathon Hinton, C. Fahey, B. Fu, Sajani Swamy, G. Dalgliesh, B. Teh, P. Deloukas, Fengtang Yang, Peter Campbell, P. Futreal, Michael Stratton (2010)
Signatures of mutation and selection in the cancer genomeNature, 463
Ada Congrains, K. Kamide, M. Ohishi, H. Rakugi (2013)
ANRIL: Molecular Mechanisms and Implications in Human HealthInternational Journal of Molecular Sciences, 14
L. Ward, Manolis Kellis (2011)
HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variantsNucleic Acids Research, 40
Hormozdiari (2016)
Colocalization of GWAS and eQTL signals detects target genesAm. J. Hum. Genet., 99
J. Liu, S. Sommeren, Hailiang Huang, S. Ng, R. Alberts, A. Takahashi, S. Ripke, James Lee, L. Jostins, T. Shah, S. Abedian, J. Cheon, Judy Cho, N. Daryani, L. Franke, Y. Fuyuno, A. Hart, R. Juyal, G. Juyal, W. Kim, A. Morris, H. Poustchi, W. Newman, V. Midha, T. Orchard, H. Vahedi, A. Sood, J. Sung, R. Malekzadeh, H. Westra, K. Yamazaki, Suk-Kyun Yang, J. Barrett, A. Franke, B. Alizadeh, M. Parkes, T. K, M. Daly, M. Kubo, C. Anderson, R. Weersma (2015)
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populationsNature Genetics, 47
T. Raj, K. Rothamel, S. Mostafavi, Chun Ye, Mark Lee, J. Replogle, T. Feng, Michelle Lee, Natasha Asinovski, I. Frohlich, S. Imboywa, Alina Korff, Y. Okada, N. Patsopoulos, Scott Davis, C. McCabe, H. Paik, G. Srivastava, S. Raychaudhuri, D. Hafler, D. Koller, A. Regev, N. Hacohen, D. Mathis, C. Benoist, B. Stranger, P. Jager (2014)
Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in LeukocytesScience, 344
J. Lennard-Jones (1989)
Classification of inflammatory bowel disease.Scandinavian journal of gastroenterology. Supplement, 170
Ho-Su Lee, S. Park, Suk-Kyun Yang, Jungbok Lee, J. Soh, Seohyun Lee, J. Bae, H. Lee, Dong-Hoon Yang, Kyung-Jo Kim, Byong Yea, J. Byeon, S. Myung, Y. Yoon, C. Yu, Jin-Ho Kim (2015)
Long-term prognosis of ulcerative colitis and its temporal change between 1977 and 2013: a hospital-based cohort study from Korea.Journal of Crohn's & colitis, 9 2
F. Hormozdiari, M. Bunt, A. Segrè, Xiao Li, J. Joo, Michael Bilow, J. Sul, S. Sankararaman, B. Pasaniuc, E. Eskin (2016)
Colocalization of GWAS and eQTL Signals Detects Target GenesbioRxiv
Aashiq Mirza, Claus Berthelsen, S. Seemann, Xiaoyong Pan, K. Frederiksen, M. Vilién, J. Gorodkin, F. Pociot (2015)
Transcriptomic landscape of lncRNAs in inflammatory bowel diseaseGenome Medicine, 7
H. Souza, C. Fiocchi (2016)
Immunopathogenesis of IBD: current state of the artNature Reviews Gastroenterology &Hepatology, 13
C. Cudejko, K. Wouters, L. Fuentes, S. Hannou, Charlotte Paquet, K. Bantubungi, Emmanuel Bouchaert, Jonathan Vanhoutte, S. Fleury, P. Rémy, A. Tailleux, G. Chinetti-Gbaguidi, D. Dombrowicz, B. Staels, R. Paumelle (2011)
p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages.Blood, 118 9
J. Barrett, B. Fry, J. Maller, M. Daly (2005)
Haploview: analysis and visualization of LD and haplotype mapsBioinformatics, 21 2
Suk-Kyun Yang, Myunghee Hong, Wanting Zhao, Yusun Jung, N. Tayebi, B. Ye, Kyung-Jo Kim, S. Park, Inchul Lee, H. Shin, H. Cheong, L. Kim, Hyo-Jong Kim, S. Jung, D. Kang, H. Youn, Jianjun Liu, K. Song (2013)
Genome-Wide Association Study of Ulcerative Colitis in Koreans Suggests Extensive Overlapping of Genetic Susceptibility With CaucasiansInflammatory Bowel Diseases, 19
Maiko Narahara, K. Higasa, Seiji Nakamura, Y. Tabara, T. Kawaguchi, M. Ishii, K. Matsubara, F. Matsuda, R. Yamada (2014)
Large-Scale East-Asian eQTL Mapping Reveals Novel Candidate Genes for LD Mapping and the Genomic Landscape of Transcriptional Effects of Sequence VariantsPLoS ONE, 9
Bryan Howie, P. Donnelly, J. Marchini (2009)
A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association StudiesPLoS Genetics, 5
N. Sharpless, C. Sherr (2015)
Forging a signature of in vivo senescenceNature Reviews Cancer, 15
Y. Fuyuno, K. Yamazaki, A. Takahashi, M. Esaki, T. Kawaguchi, M. Takazoe, T. Matsumoto, T. Matsui, Hiroki Tanaka, S. Motoya, Yasuo Suzuki, Y. Kiyohara, T. Kitazono, M. Kubo (2016)
Genetic characteristics of inflammatory bowel disease in a Japanese populationJournal of Gastroenterology, 51
Yan Liu, H. Sanoff, Hyunsoon Cho, C. Burd, C. Torrice, K. Mohlke, J. Ibrahim, N. Thomas, N. Sharpless (2009)
INK4/ARF Transcript Expression Is Associated with Chromosome 9p21 Variants Linked to AtherosclerosisPLoS ONE, 4
E. Zeggini, M. Weedon, C. Lindgren, T. Frayling, K. Elliott, H. Lango, N. Timpson, J. Perry, N. Rayner, R. Freathy, J. Barrett, B. Shields, A. Morris, S. Ellard, C. Groves, L. Harries, J. Marchini, K. Owen, B. Knight, L. Cardon, M. Walker, G. Hitman, A. Morris, A. Doney, M. McCarthy, A. Hattersley (2007)
Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 DiabetesScience, 316
R. Myers, J. Stamatoyannopoulos, M. Snyder, I. Dunham, R. Hardison, B. Bernstein, T. Gingeras, W. Kent, E. Birney, B. Wold, G. Crawford, C. Epstein, N. Shoresh, J. Ernst, T. Mikkelsen, P. Kheradpour, Xiaolan Zhang, Li Wang, R. Issner, Michael Coyne, Timothy Durham, Manching Ku, Thanh Truong, L. Ward, Robert Altshuler, Michael Lin, Manolis Kellis, Carrie Davis, P. Kapranov, A. Dobin, C. Zaleski, F. Schlesinger, P. Batut, S. Chakrabortty, Sonali Jha, Wei Lin, J. Drenkow, Huaien Wang, K. Bell, I. Bell, Hui Gao, E. Dumais, Jacqueline Dumais, S. Antonarakis, C. Ucla, C. Borel, R. Guigó, S. Djebali, Julien Lagarde, C. Kingswood, Paolo Ribeca, M. Sammeth, T. Alioto, A. Merkel, Hagen Tilgner, Piero Carninci, Y. Hayashizaki, T. Lassmann, Hazuki Takahashi, Rehab Abdelhamid, G. Hannon, Katalin Fejes, Jonathan Preall, Assaf Gordon, V. Sotirova, A. Reymond, C. Howald, Emilie Graison, Jacqueline Chrast, Y. Ruan, Xiaoan Ruan, A. Shahab, W. Poh, Chia-Lin Wei, T. Furey, A. Boyle, Nathan Sheffield, Lingyun Song, Yoichiro Shibata, T. Vales, D. Winter, Zhancheng Zhang, D. London, Tian-yuan Wang, Damian Keefe, V. Iyer, Bum-Kyu Lee, Ryan McDaniell, Zheng Liu, Anna Battenhouse, A. Bhinge, J. Lieb, L. Grasfeder, Kimberly Showers, P. Giresi, Seul Kim, Christopher Shestak, Florencia Pauli, Timothy Reddy, Jason Gertz, E. Partridge, Preti Jain, Rebekka Sprouse, A. Bansal, Barbara Pusey, M. Muratet, K. Varley, K. Bowling, Kimberly Newberry, Amy Nesmith, Jason Dilocker, S. Parker, L. Waite, Krista Thibeault, Kevin Roberts, D. Absher, A. Mortazavi, B. Williams, G. Marinov, Diane Trout, Brandon King, Kenneth McCue, Anthony Kirilusha, Gilberto Desalvo, Katherine Fisher, Henry Amrhein, S. Pepke, J. Vielmetter, G. Sherlock, A. Sidow, S. Batzoglou, Rami Rauch, A. Kundaje, Maxwell Libbrecht, E. Margulies, Stephen Parker, L. Elnitski, E. Green, T. Hubbard, J. Harrow, S. Searle, F. Kokocinski, B. Aken, A. Frankish, T. Hunt, Gloria Despacio-Reyes, M. Kay, Gaurab Mukherjee, A. Bignell, Gary Saunders, Veronika Boychenko, M. Brent, M. Baren, Randall Brown, M. Gerstein, Ekta Khurana, S. Balasubramanian, Hugo Lam, Philip Cayting, R. Robilotto, Z. Lu, T. Derrien, Andrea Tanzer, David Knowles, M. Mariotti, D. Haussler, R. Harte, M. Diekhans, A. Valencia, M. Tress, S. Landt, D. Raha, Minyi Shi, G. Euskirchen, Fabian Grubert, Maya Kasowski, Jin Lian, P. Lacroute, Youhan Xu, Hannah Monahan, Dorrelyn Patacsil, T. Slifer, Xinqiong Yang, Alexandra Charos, Brian Reed, Linfeng Wu, Raymond Auerbach, L. Habegger, M. Hariharan, J. Rozowsky, A. Abyzov, S. Weissman, K. Struhl, Nathan Lamarre-Vincent, Marianne Lindahl-Allen, B. Miotto, Z. Moqtaderi, J. Fleming, P. Newburger, P. Farnham, S. Frietze, H. O’Geen, Xiaoqin Xu, Kimberly Blahnik, Alina Cao, Sushma Iyengar, R. Kaul, R. Thurman, Hao Wang, P. Navas, R. Sandstrom, P. Sabo, M. Weaver, T. Canfield, Kristen Lee, Shane Neph, Vaughan Roach, Alex Reynolds, Audra Johnson, Eric Rynes, Erika Giste, Shinny Vong, Jun Neri, Tristan Frum, Eric Nguyen, Abigail Ebersol, Minerva Sanchez, Hadar Sheffer, D. Lotakis, E. Haugen, R. Humbert, T. Kutyavin, Tony Shafer, William Noble, J. Dekker, B. Lajoie, Amartya Sanyal, K. Rosenbloom, T. Dreszer, B. Raney, G. Barber, L. Meyer, C. Sloan, V. Malladi, M. Cline, K. Learned, Vanessa Swing, A. Zweig, B. Rhead, P. Fujita, K. Roskin, D. Karolchik, R. Kuhn, S. Wilder, D. Sobral, Javier Herrero, Kathryn Beal, M. Lukk, A. Brazma, Juan Vaquerizas, N. Luscombe, P. Bickel, Nathan Boley, James Brown, Qunhua Li, Haiyan Huang, A. Sboner, Kevin Yip, Chao Cheng, Koon-Kiu Yan, N. Bhardwaj, Jing Wang, L. Lochovsky, J. Jee, Theodore Gibson, Jing Leng, Jiang Du, Robert Harris, Giltae Song, W. Miller, Bernard Suh, B. Paten, M. Hoffman, Orion Buske, Z. Weng, Xianjun Dong, Jie Wang, H. Xi, S. Tenenbaum, F. Doyle, S. Chittur, L. Penalva, T. Tullius, K. White, S. Karmakar, Alec Victorsen, Nader Jameel, N. Bild, R. Grossman, P. Collins, N. Trinklein, Morgan Giddings, Jainab Khatun, Christopher Maier, Ting Wang, T. Whitfield, Xian Chen, Yanbao Yu, H. Gunawardena, E. Feingold, R. Lowdon, Laura Dillon, P. Good, B. Risk (2011)
A User's Guide to the Encyclopedia of DNA Elements (ENCODE)PLoS Biology, 9
Z. Huang, Buvana Manickam, V. Ryvkin, Xiaohong Zhou, G. Fantuzzi, T. Mazzone, Susan Sam (2013)
PCOS is associated with increased CD11c expression and crown-like structures in adipose tissue and increased central abdominal fat depots independent of obesity.The Journal of clinical endocrinology and metabolism, 98 1
K. Ardlie, D. DeLuca, A. Segrè, T. Sullivan, Taylor Young, Ellen Gelfand, Casandra Trowbridge, J. Maller, T. Tukiainen, M. Lek, L. Ward, P. Kheradpour, B. Iriarte, Y. Meng, Cameron Palmer, T. Esko, W. Winckler, J. Hirschhorn, Manolis Kellis, D. MacArthur, G. Getz, A. Shabalin, Gen Li, Yi‐Hui Zhou, A. Nobel, I. Rusyn, F. Wright, T. Lappalainen, Pedro Ferreira, H. Ongen, M. Rivas, A. Battle, S. Mostafavi, Jean Monlong, M. Sammeth, Marta Melé, F. Reverter, Jakob Goldmann, D. Koller, R. Guigó, M. McCarthy, E. Dermitzakis, E. Gamazon, H. Im, A. Konkashbaev, D. Nicolae, N. Cox, T. Flutre, X. Wen, M. Stephens, J. Pritchard, Zhidong Tu, Bin Zhang, Tao Huang, Q. Long, Luan Lin, Jialiang Yang, Jun Zhu, Jun Liu, A. Brown, B. Mestichelli, D. Tidwell, E. Lo, Mike Salvatore, Saboor Shad, Jeffrey Thomas, J. Lonsdale, M. Moser, Bryan Gillard, E. Karasik, K. Ramsey, Christopher Choi, B. Foster, John Syron, Johnelle Fleming, Harold Magazine, R. Hasz, Gary Walters, J. Bridge, Mark Miklos, Susan Sullivan, Laura Barker, H. Traino, M. Mosavel, L. Siminoff, Dana Valley, D. Rohrer, S. Jewell, P. Branton, L. Sobin, M. Barcus, L. Qi, J. McLean, P. Hariharan, K. Um, Shenpei Wu, D. Tabor, C. Shive, Anna Smith, Stephen Buia, Anita Undale, Karna Robinson, Nancy Roche, Kimberly Valentino, A. Britton, R. Burges, Debra Bradbury, Kenneth Hambright, John Seleski, G. Korzeniewski, Kenyon Erickson, Yvonne Marcus, J. Tejada, M. Taherian, Chunrong Lu, Margaret Basile, D. Mash, S. Volpi, J. Struewing, Gary Temple, Joy Boyer, Deborah Colantuoni, R. Little, S. Koester, Latarsha Carithers, Helen Moore, P. Guan, C. Compton, Sherilyn Sawyer, J. Demchok, J. Vaught, C. Rabiner, Lockhart (2015)
The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humansScience, 348
Jesse Dixon, Siddarth Selvaraj, Feng Yue, Audrey Kim, Yan Li, Yin Shen, Ming Hu, Jun Liu, B. Ren (2012)
Topological Domains in Mammalian Genomes Identified by Analysis of Chromatin InteractionsNature, 485
H. Westra, M. Peters, T. Esko, H. Yaghootkar, C. Schurmann, J. Kettunen, M. Christiansen, B. Fairfax, K. Schramm, J. Powell, A. Zhernakova, D. Zhernakova, J. Veldink, L. Berg, J. Karjalainen, S. Withoff, A. Uitterlinden, A. Hofman, F. Rivadeneira, P. Hoen, E. Reinmaa, K. Fischer, M. Nelis, L. Milani, D. Melzer, L. Ferrucci, A. Singleton, D. Hernandez, M. Nalls, G. Homuth, M. Nauck, D. Radke, U. Völker, M. Perola, V. Salomaa, Jennifer Brody, Astrid Suchy-Dicey, S. Gharib, D. Enquobahrie, T. Lumley, G. Montgomery, Seiko Makino, H. Prokisch, C. Herder, M. Roden, H. Grallert, T. Meitinger, K. Strauch, Yang Li, R. Jansen, P. Visscher, J. Knight, B. Psaty, S. Ripatti, A. Teumer, T. Frayling, A. Metspalu, J. Meurs, L. Franke (2013)
Systematic identification of trans eQTLs as putative drivers of known disease associationsNature Genetics, 45
Kouichi Asano, Tomonaga Matsushita, J. Umeno, N. Hosono, A. Takahashi, T. Kawaguchi, T. Matsumoto, T. Matsui, Y. Kakuta, Y. Kinouchi, T. Shimosegawa, M. Hosokawa, Y. Arimura, Y. Shinomura, Y. Kiyohara, T. Tsunoda, N. Kamatani, M. Iida, Yusuke Nakamura, M. Kubo (2009)
A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese populationNature Genetics, 41
Suk-Kyun Yang, Myunghee Hong, Hyunchul Choi, Wanting Zhao, Yusun Jung, T. Haritunians, B. Ye, Kyung-Jo Kim, S. Park, Inchul Lee, W. Kim, J. Cheon, Young-Ho Kim, B. Jang, Hyunsoo Kim, J. Choi, J. Koo, J. Lee, S. Jung, H. Shin, D. Kang, H. Youn, K. Taylor, J. Rotter, Jianjun Liu, D. McGovern, K. Song (2015)
Immunochip Analysis Identification of 6 Additional Susceptibility Loci for Crohn's Disease in KoreansInflammatory Bowel Diseases, 21
K. Lange, L. Moutsianas, James Lee, C. Lamb, Yang Luo, N. Kennedy, L. Jostins, D. Rice, Javier Gutiérrez-Achury, S. Ji, G. Heap, E. Nimmo, C. Edwards, P. Henderson, C. Mowat, J. Sanderson, J. Satsangi, A. Simmons, D. Wilson, M. Tremelling, A. Hart, C. Mathew, W. Newman, M. Parkes, C. Lees, H. Uhlig, C. Hawkey, N. Prescott, T. Ahmad, J. Mansfield, C. Anderson, J. Barrett (2016)
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel diseaseNature genetics, 49
Suk-Kyun Yang, Myunghee Hong, Hyunjung Oh, H. Low, Seulgi Jung, Seonjoo Ahn, Youngjin Kim, J. Baek, Cue Lee, Eunji Kim, K. Kim, B. Ye, Kyung-Jo Kim, S. Park, Ho-Su Lee, Inchul Lee, H. Shin, B. Han, D. McGovern, Jianjun Liu, K. Song (2016)
Identification of Loci at 1q21 and 16q23 That Affect Susceptibility to Inflammatory Bowel Disease in Koreans.Gastroenterology, 151 6
M. Cunnington, M. Koref, B. Mayosi, J. Burn, B. Keavney (2010)
Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL ExpressionPLoS Genetics, 6
S. Hannou, K. Wouters, R. Paumelle, B. Staels (2015)
Functional genomics of the CDKN2A/B locus in cardiovascular and metabolic disease: what have we learned from GWASs?Trends in Endocrinology & Metabolism, 26
Suk-Kyun Yang, Myunghee Hong, Wanting Zhao, Yusun Jung, J. Baek, N. Tayebi, K. Kim, B. Ye, Kyung-Jo Kim, S. Park, Inchul Lee, Eun-Ju Lee, W. Kim, J. Cheon, Young-Ho Kim, B. Jang, Hyunsoo Kim, J. Choi, J. Koo, J. Lee, S. Jung, Y. Lee, J. Jang, H. Shin, D. Kang, H. Youn, Jianjun Liu, K. Song (2013)
Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populationsGut, 63
IntroductionInflammatory bowel disease (IBD) is characterized by chronic inflammation in the gastrointestinal tract, presumably due to dysregulation of the microbial flora in genetically susceptible individuals. Recent large‐scale genome‐wide association studies (GWASs) in populations of the European ancestry advanced our understanding of IBD‐related genetics by identifying over 241 susceptibility loci for IBD. However, the known variants only account for a fraction of IBD heritability. Despite differences in the clinical characteristics of IBD across different ethnic groups, there are limited number of studies in non‐European populations. Several GWAS on Crohn's disease (CD) and ulcerative colitis (UC) performed in Asian populations reported a total of five Asian‐specific loci. Our recent largest‐to‐date Asian‐specific GWAS of IBD provided suggestive evidence of association signals in the cyclin‐dependent kinase inhibitor 2A/B (CDKN2A/CDKN2B) locus.Polymorphisms in the CDKN2A/CDKN2B region at 9p21 are associated with various types of cancer and heart and inflammatory diseases. The CDKN2A/CDKN2B locus contains three tumor suppressor genes, p14ARF, p16INK4A, and p15INK4B, all of which are involved in the retinoblastoma and p53 pathway. Multiple studies found disruption of the CDKN2A/CDKN2B genes in malignant tumors, implying their function in cell‐cycle regulation. Recent GWAS identified additional risk variants in the CDKN2B antisense RNA 1 (CDKN2B‐AS1, also called
Journal of Gastroenterology and Hepatology – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.