Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Association between GOLGB1 tag‐polymorphisms and nonsyndromic cleft palate only in the Brazilian population

Association between GOLGB1 tag‐polymorphisms and nonsyndromic cleft palate only in the Brazilian... Nonsyndromic oral clefts are common congenital birth defects that exhibit variable prevalence around the world, often influenced by population‐dependent genetic predisposition. Few studies have been performed with nonsyndromic cleft palate only (NSCPO), limiting the knowledge of the genetic risk factors related to this type of oral cleft. Genetic variants in golgin subfamily B member 1 (GOLGB1), a gene that is essential for normal murine palatogenesis, were analyzed in this study to establish its potential association with NSCPO risk in the Brazilian population. Five tag‐single nucleotide polymorphisms (SNPs) of GOLGB1 (rs1169, rs7153, rs9968051, rs9819530, and rs6794341), which capture the majority of alleles spanning within gene, were genotyped in a case–control study with 270 patients with NSCPO and 284 unrelated healthy controls. The samples were also genotyped for 40 biallelic polymorphic markers to characterize the genetic ancestry. After adjustment for co‐variants, the GOLGB1 tag‐SNPs and the haplotypes formed by those SNPs were not significantly associated with NSCPO in this Brazilian case–control cohort. Our results suggest that common polymorphisms of GOLGB1 are not associated NSCPO susceptibility in the Brazilian population. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Association between GOLGB1 tag‐polymorphisms and nonsyndromic cleft palate only in the Brazilian population

Download PDF
5 pages

Loading next page...
 
/lp/wiley/association-between-golgb1-tag-polymorphisms-and-nonsyndromic-cleft-008kl8wgpr
Publisher
Wiley
Copyright
Copyright © 2018 John Wiley & Sons Ltd/University College London
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/ahg.12242
Publisher site
See Article on Publisher Site

Abstract

Nonsyndromic oral clefts are common congenital birth defects that exhibit variable prevalence around the world, often influenced by population‐dependent genetic predisposition. Few studies have been performed with nonsyndromic cleft palate only (NSCPO), limiting the knowledge of the genetic risk factors related to this type of oral cleft. Genetic variants in golgin subfamily B member 1 (GOLGB1), a gene that is essential for normal murine palatogenesis, were analyzed in this study to establish its potential association with NSCPO risk in the Brazilian population. Five tag‐single nucleotide polymorphisms (SNPs) of GOLGB1 (rs1169, rs7153, rs9968051, rs9819530, and rs6794341), which capture the majority of alleles spanning within gene, were genotyped in a case–control study with 270 patients with NSCPO and 284 unrelated healthy controls. The samples were also genotyped for 40 biallelic polymorphic markers to characterize the genetic ancestry. After adjustment for co‐variants, the GOLGB1 tag‐SNPs and the haplotypes formed by those SNPs were not significantly associated with NSCPO in this Brazilian case–control cohort. Our results suggest that common polymorphisms of GOLGB1 are not associated NSCPO susceptibility in the Brazilian population.

Journal

Annals of Human Genetics – Wiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

  • Polymorphisms at regions 1p22.1 (rs560426) and 8q24 (rs1530300) are risk markers for nonsyndromic cleft lip and/or palate in the Brazilian population
    Bagordakis, E.; Paranaiba, L. M.; Brito, L. A.; Aquino, S. N.; Messetti, A. C.; Martelli‐Junior, H.; Coletta, R. D.
  • Genetic factors influencing risk to orofacial clefts: Today's challenges and tomorrow's opportunities
    Beaty, T. H.; Marazita, M. L.; Leslie, E. J.
  • Evidence for gene‐environment interaction in a genome wide study of nonsyndromic cleft palate
    Beaty, T. H.; Ruczinski, I.; Murray, J. C.; Marazita, M. L.; Munger, R. G.; Hetmanski, J. B.; Scott, A. F.
  • Epidemiology, etiology, and treatment of isolated cleft palate
    Burg, M. L.; Chai, Y.; Yao, C. A.; Magee, W.; Figueiredo, J. C.
  • Analysis of susceptibility polymorphisms for nonsyndromic cleft lip with or without cleft palate in the Brazilian population
    Aquino, S. N.; Messetti, A. C.; Hoshi, R.; Borges, A.; Viena, C. S.; Reis, S. R.; Coletta, R. D.
  • Efficiency and power in genetic association studies
    Bakker, P. I.; Yelensky, R.; Pe'er, I.; Gabriel, S. B.; Daly, M. J.; Altshuler, D.
  • Genetic risk factors for nonsyndromic cleft lip with or without cleft palate in a Brazilian population with high African ancestry
    do Rego Borges, A.; Sá, J.; Hoshi, R.; Viena, C. S.; Mariano, L. C.; Castro Veiga, P.; Reis, S. R.
  • Insertional mutation in the Golgb1 gene is associated with osteochondrodysplasia and systemic edema in the OCD rat
    Katayama, K.; Sasaki, T.; Goto, S.; Ogasawara, K.; Maru, H.; Suzuki, K.; Suzuki, H.
  • Golgb1 regulates protein glycosylation and is crucial for mammalian palate development
    Lan, Y.; Zhang, N.; Liu, H.; Xu, J.; Jiang, R.
  • A genome‐wide association study of nonsyndromic cleft palate identifies an etiologic missense variant in GRHL3
    Leslie, E. J.; Liu, H.; Carlson, J. C.; Shaffer, J. R.; Feingold, E.; Wehby, G.; Marazita, M. L.
  • Association between genes involved in craniofacial development and nonsyndromic cleft lip and/or palate in the Brazilian population
    Machado, R. A.; Messetti, A. C.; Aquino, S. N.; Martelli‐Júnior, H.; Swerts, M. S.; Almeida Reis, S. R.; Coletta, R. D.
  • Prevalence of nonsyndromic oral clefts in a reference hospital in the state of Minas Gerais, Brazil, between 2000–2005
    Martelli‐Junior, H.; Porto, L. V.; Martelli, D. R.; Bonan, P. R.; Freitas, A. B.; Della Coletta, R.
  • Brazilian multicenter study of association between polymorphisms in CRISPLD2 and JARID2 and non‐syndromic oral clefts
    Messetti, A. C.; Machado, R. A.; Oliveira, C. E.; Martelli‐Júnior, H.; Almeida Reis, S. R.; Moreira, H. S.; Coletta, R. D.
  • The golgin coiled‐coil proteins of the Golgi apparatus
    Munro, S.
  • Lack of association between IRF6 polymorphisms (rs2235371 and rs642961) and non‐syndromic cleft lip and/or palate in a Brazilian population
    Paranaiba, L. M.; Bufalino, A.; Martelli‐Junior, H.; Barros, L. M.; Graner, E.; Coletta, R. D.
  • Inference of population structure using multilocus genotype data
    Pritchard, J. K.; Stephens, M.; Donnelly, P.
  • Giantin interacts with both the small GTPase Rab6 and Rab1
    Rosing, M.; Ossendorf, E.; Rak, A.; Barnekow, A.