Association between bone loss in periodontal disease and polymorphism of N‐acetyltransferase (NAT2)

Association between bone loss in periodontal disease and polymorphism of N‐acetyltransferase... Background: The individual susceptibility to periodontal disease is probably the result of an interaction of multiple genetic and environmental influences. Polymorphism of the N‐acetyltransferase (NAT 2) modifies the individual susceptibility to toxicity from certain therapeutic drugs or heterocyclic amines including substances from cigarette smoke. Subjects are to be classified as ‘slow’ or ‘rapid’ acetylators according to how fast their bodies metabolise such xenobiotics. Differences in their ability to detoxify these substances may contribute to an increased risk for periodontitis in subjects exposed to cigarette smoke or other xenobiotics. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Periodontology Wiley

Association between bone loss in periodontal disease and polymorphism of N‐acetyltransferase (NAT2)

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Publisher
Wiley
Copyright
Copyright © 2002 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0303-6979
eISSN
1600-051X
D.O.I.
10.1034/j.1600-051x.2002.290104.x
Publisher site
See Article on Publisher Site

Abstract

Background: The individual susceptibility to periodontal disease is probably the result of an interaction of multiple genetic and environmental influences. Polymorphism of the N‐acetyltransferase (NAT 2) modifies the individual susceptibility to toxicity from certain therapeutic drugs or heterocyclic amines including substances from cigarette smoke. Subjects are to be classified as ‘slow’ or ‘rapid’ acetylators according to how fast their bodies metabolise such xenobiotics. Differences in their ability to detoxify these substances may contribute to an increased risk for periodontitis in subjects exposed to cigarette smoke or other xenobiotics.

Journal

Journal of Clinical PeriodontologyWiley

Published: Jan 1, 2002

Keywords: ; ; ; ;

References

  • Factors associated with adult periodontitis in a dental teaching clinic population
    Gelskey, S. C.; Young, T. K.; Singer, D. L.
  • A socio‐ecologic model for periodontal diseases
    Hansen, B. F.; Bjertness, E.; Grönnesby, J. K.
  • Genetic factors in the pathogenesis of periodontitis
    Hart, T.; Kornman, K. S.
  • Statistical management of periodontal data
    Kingman, A.
  • The interleukin‐1 genotype as a severity factor in adult periodontal disease
    Kornman, K. S.; Crane, A.; Wang, H. Y.; Di Giovine, F. S.; Newman, M. G.; Pirk, F. W.; Wilson, T. G.; Higginbottom, F.L.; Duff, G. W.

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