J Clin Lab Anal. 2018;32:e22283. wileyonlinelibrary.com/journal/jcla
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© 2017 Wiley Periodicals, Inc.
Are visceral adiposity index and lipid accumulation product
reliable indices for metabolic disturbances in patients with type
2 diabetes mellitus?
| Aleksandra Klisic
| Ana Ninic
Primary Health Care Center, Podgorica,
Biochemistry, University of Belgrade- Faculty
of Pharmacy, Belgrade, Serbia
Aleksandra Klisic, Center of Laboratory
Diagnostics, Primary Health Care Center,
Technological Development, Republic of
Serbia, Grant/Award Number: 175035
Background: Visceral adiposity index (VAI) and Lipid accumulation product (LAP) are
novel visceral adiposity indexes, proposed for the evaluation of cardiometabolic risk in
adult population. Considering contradictory results obtained from many studies so far,
we aimed to examine the potential benefit of applicability of VAI and LAP, over simple
anthropometric indices and traditional lipid parameters in individuals with type 2 dia-
to participate in this cross- sectional study were enrolled. Anthropometric and biochemi-
cal parameters, as well as blood pressure were obtained. VAI and LAP were calculated.
cholesterol (HDL- c), (P<.001), waist circumference (WC), (P=.027), age (P=.001), hy-
polipemic therapy (P=.024), and LAP (P=.005)wereindependentpredictorsofDM2in
In Receiver Operating Characteristic curve analysis, used to discriminate subjects with
only achieved with models which were consisted of parameters used in VAI (Body
mass index, WC, HDL- c, triglycerides) and LAP (WC, triglycerides) indexes equations,
not with VAI (AUC=0.781) and LAP (AUC=0.784) indexes themselves.
Conclusion: Visceral adiposity index and Lipid accumulation product may not be better
than parameters that enter its equation in type 2 diabetes prediction.
lipid accumulation product, obesity, type 2 diabetes mellitus, visceral adiposity index
1 | INTRODUCTION
A growing proportion of individuals with type 2 diabetes mellitus
mass, especially in intra- abdominal (visceral) region.
tissue is regarded to be metabolically active endocrine organ, secret-
ing a variety of pro- inflammatory adipokines, thus further leading to
many cardiometabolic disorders.
Simple anthropometric parameter of abdominal adiposity such
as waist circumference (WC) is established and widely used in many
As early recognition and treatment of individuals
with abdominal adiposity is of utmost importance in reducing car-
diometabolic risk, some novel visceral adiposity markers, such as vis-
ceral adiposity index (VAI) and the lipid accumulation product (LAP)
have been validated so far.
The VAI is gender- specific mathematical model that uses both
anthropometric indices [e.g., body mass index (BMI) and WC] and
lipid parameters [e.g., high- density lipoprotein cholesterol (HDL- c)
and triglycerides (TG)] in its equation, and is highly correlated with
visceral adiposity as measured with the gold standard method, such