Are visceral adiposity index and lipid accumulation product reliable indices for metabolic disturbances in patients with type 2 diabetes mellitus?

Are visceral adiposity index and lipid accumulation product reliable indices for metabolic... INTRODUCTIONA growing proportion of individuals with type 2 diabetes mellitus (DM2) worldwide is attributed in large part to the increase in body fat mass, especially in intra‐abdominal (visceral) region. Visceral adipose tissue is regarded to be metabolically active endocrine organ, secreting a variety of pro‐inflammatory adipokines, thus further leading to many cardiometabolic disorders.Simple anthropometric parameter of abdominal adiposity such as waist circumference (WC) is established and widely used in many investigations. As early recognition and treatment of individuals with abdominal adiposity is of utmost importance in reducing cardiometabolic risk, some novel visceral adiposity markers, such as visceral adiposity index (VAI) and the lipid accumulation product (LAP) have been validated so far.The VAI is gender‐specific mathematical model that uses both anthropometric indices [e.g., body mass index (BMI) and WC] and lipid parameters [e.g., high‐density lipoprotein cholesterol (HDL‐c) and triglycerides (TG)] in its equation, and is highly correlated with visceral adiposity as measured with the gold standard method, such as magnetic resonance imaging. The LAP is a gender‐specific index based on a combination of WC and TG in its equation. Both of these indexes are proposed as simple, accurate, and low‐cost tools for the evaluation of visceral adipose tissue dysfunction and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Laboratory Analysis Wiley

Are visceral adiposity index and lipid accumulation product reliable indices for metabolic disturbances in patients with type 2 diabetes mellitus?

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 Wiley Periodicals, Inc.
ISSN
0887-8013
eISSN
1098-2825
D.O.I.
10.1002/jcla.22283
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONA growing proportion of individuals with type 2 diabetes mellitus (DM2) worldwide is attributed in large part to the increase in body fat mass, especially in intra‐abdominal (visceral) region. Visceral adipose tissue is regarded to be metabolically active endocrine organ, secreting a variety of pro‐inflammatory adipokines, thus further leading to many cardiometabolic disorders.Simple anthropometric parameter of abdominal adiposity such as waist circumference (WC) is established and widely used in many investigations. As early recognition and treatment of individuals with abdominal adiposity is of utmost importance in reducing cardiometabolic risk, some novel visceral adiposity markers, such as visceral adiposity index (VAI) and the lipid accumulation product (LAP) have been validated so far.The VAI is gender‐specific mathematical model that uses both anthropometric indices [e.g., body mass index (BMI) and WC] and lipid parameters [e.g., high‐density lipoprotein cholesterol (HDL‐c) and triglycerides (TG)] in its equation, and is highly correlated with visceral adiposity as measured with the gold standard method, such as magnetic resonance imaging. The LAP is a gender‐specific index based on a combination of WC and TG in its equation. Both of these indexes are proposed as simple, accurate, and low‐cost tools for the evaluation of visceral adipose tissue dysfunction and

Journal

Journal of Clinical Laboratory AnalysisWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

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