APLASTIC CRISES IN HAEMOLYTIC ANAEMIAS: THE ROLE OF A PARVOVIRUS‐LIKE AGENT

APLASTIC CRISES IN HAEMOLYTIC ANAEMIAS: THE ROLE OF A PARVOVIRUS‐LIKE AGENT In 1981 Pattison et al detected a parvovirus-like agent (PVLA) in sera from six children with sickle cell anaemia (SCA) who had had aplastic crises. Evidence of PVLA infection has since been found in eight more cases of SCA in the U.K. (Anderson, 1982), 24 in Jamaica (Serjeant et al, 1981) and six in the U.S.A. (Rao et al, 1983). Similar crises associated with PVLA infection have also been reported in hereditary spherocytosis (HS) by Kelleher et al(l982), in pyruvate kinase deficiency (PK) by Duncan & Kertz (1982), and in untransfused thalassaemia intermedia by Rao et al (1 8 3). PVLA infection probably occurs worldwide, 9 having been identified in West Africa (Pattison, 1983, unpublished observation) and Australia (Schneerson et al, 1980, quoting Cossart); as well as in the U.K., the U.S.A. and Jamaica. Together these findings suggest that PVLA could be the cause of most aplastic crises in haemolytic anaemias. A retrospective study of published reports of aplastic crises in HS between 1935 and 1964 concluded that they might all have been manifestations of infection by a single agent which could have been PVLA (Mortimer, 1983). Automonous animal parvoviruses are known to have an affinity for rapidly http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Haematology Wiley

APLASTIC CRISES IN HAEMOLYTIC ANAEMIAS: THE ROLE OF A PARVOVIRUS‐LIKE AGENT

British Journal of Haematology, Volume 55 (3) – Nov 1, 1983

Loading next page...
 
/lp/wiley/aplastic-crises-in-haemolytic-anaemias-the-role-of-a-parvovirus-like-m5JiPl4Brw
Publisher
Wiley
Copyright
Copyright © 1983 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0007-1048
eISSN
1365-2141
D.O.I.
10.1111/j.1365-2141.1983.tb02153.x
Publisher site
See Article on Publisher Site

Abstract

In 1981 Pattison et al detected a parvovirus-like agent (PVLA) in sera from six children with sickle cell anaemia (SCA) who had had aplastic crises. Evidence of PVLA infection has since been found in eight more cases of SCA in the U.K. (Anderson, 1982), 24 in Jamaica (Serjeant et al, 1981) and six in the U.S.A. (Rao et al, 1983). Similar crises associated with PVLA infection have also been reported in hereditary spherocytosis (HS) by Kelleher et al(l982), in pyruvate kinase deficiency (PK) by Duncan & Kertz (1982), and in untransfused thalassaemia intermedia by Rao et al (1 8 3). PVLA infection probably occurs worldwide, 9 having been identified in West Africa (Pattison, 1983, unpublished observation) and Australia (Schneerson et al, 1980, quoting Cossart); as well as in the U.K., the U.S.A. and Jamaica. Together these findings suggest that PVLA could be the cause of most aplastic crises in haemolytic anaemias. A retrospective study of published reports of aplastic crises in HS between 1935 and 1964 concluded that they might all have been manifestations of infection by a single agent which could have been PVLA (Mortimer, 1983). Automonous animal parvoviruses are known to have an affinity for rapidly

Journal

British Journal of HaematologyWiley

Published: Nov 1, 1983

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off