AO 001WINDS OF CHANGE: BRONCHODILATOR RESPONSIVENESS FROM MORE THAN ONE DIRECTIONPloen L1, Southwell P2, Micalos P3, Swanney M11Canterbury District Health Board, Christchurch, New Zealand, 2Charles Sturt University, Orange, Australia, 3Charles Sturt University, Bathurst, AustraliaIntroductionPositive bronchodilator responsiveness (BR) using current American Thoracic Society and European Respiratory Society (ATS/ERS) criteria, purportedly ensures spirometric variability is significantly exceeded. The ATS/ERS guidelines acknowledge there is no clear consensus about what constitutes bronchodilator responsiveness in subjects with airflow obstruction.AimThis study investigated the individual variability in multiple spirometric parameters in patients having reversibility tests. We address how spirometric variability can inform current guidelines for identifying a clinically significant bronchodilator response.Method102 consenting participants performed slow vital capacity (SVC) and flow volume loops (FVL) before and after Salbutamol administration. Measurement of symptom control used the clinical chronic obstructive pulmonary disease questionnaire and dyspnoea and wheeze used the visual analogue scale. Two determinants of BR: ATS/ERS criteria and a t‐score calculation were compared by correlation with the subjective measurements of respiratory impairment.Results63 participants had positive bronchodilator responses by t‐score calculation compared with 16 by current ATS/ERS guidelines. T‐scores showed a weaker correlation with subjective measures of respiratory impairment than per cent and absolute change. Inspiratory vital capacity (IVC),
Respirology – Wiley
Published: Jan 1, 2018
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