AO 001WINDS OF CHANGE: BRONCHODILATOR RESPONSIVENESS FROM MORE THAN ONE DIRECTIONPloen L1, Southwell P2, Micalos P3, Swanney M11Canterbury District Health Board, Christchurch, New Zealand, 2Charles Sturt University, Orange, Australia, 3Charles Sturt University, Bathurst, AustraliaIntroductionPositive bronchodilator responsiveness (BR) using current American Thoracic Society and European Respiratory Society (ATS/ERS) criteria, purportedly ensures spirometric variability is significantly exceeded. The ATS/ERS guidelines acknowledge there is no clear consensus about what constitutes bronchodilator responsiveness in subjects with airflow obstruction.AimThis study investigated the individual variability in multiple spirometric parameters in patients having reversibility tests. We address how spirometric variability can inform current guidelines for identifying a clinically significant bronchodilator response.Method102 consenting participants performed slow vital capacity (SVC) and flow volume loops (FVL) before and after Salbutamol administration. Measurement of symptom control used the clinical chronic obstructive pulmonary disease questionnaire and dyspnoea and wheeze used the visual analogue scale. Two determinants of BR: ATS/ERS criteria and a t‐score calculation were compared by correlation with the subjective measurements of respiratory impairment.Results63 participants had positive bronchodilator responses by t‐score calculation compared with 16 by current ATS/ERS guidelines. T‐scores showed a weaker correlation with subjective measures of respiratory impairment than per cent and absolute change. Inspiratory vital capacity (IVC),
Respirology – Wiley
Published: Jan 1, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera