Anxiolytic activity of adenosine receptor activation in mice

Anxiolytic activity of adenosine receptor activation in mice 1 Purine analogues have been examined for anxiolytic‐ and anxiogenic‐like activity in mice, by use of the elevated plus‐maze. 2 The selective A1 receptor agonist, N6‐cyclopentyladenosine (CPA) had marked anxiolytic‐like activity at 10 and 50 μ kg−1, with no effect on locomotor performance at these doses. 3 The A1 selective adenosine receptor antagonist, 1,3‐dipropyl‐8‐cyclopentylxanthine (CPX) had no significant effect on anxiety‐related measures or locomotor behaviour, but blocked the anxiolytic‐like activity of CPA. The hydrophilk xanthine, 8‐(p‐sulphophenyl) theophylline did not prevent anxiolysis by CPA. 4 Caffeine had anxiogenic‐like activity at 30 mg kg−1 which was prevented by CPA at 50 μg kg−1. 5 The A2 receptor agonist, N6‐(2‐(3,5‐dimethoxyphenyl)‐2‐(2‐methylphenyl)‐ethyl)adenosine (DPMA) had no effect on anxiety behaviour but depressed locomotor activity at the highest dose tested of 1 mg kg−1. The A2 receptor antagonist, 1,3‐dimethyl‐l‐propargylxanthine (DMPX) had no effect on anxiety‐related measures or locomotion and did not modify the anxiolytic‐like activity of CPA. 6 Administration of DPMA in combination with anxiolytic doses of CPA prevented the anxiolytic‐like activity of the latter. 7 The results suggest that the selective activation of central A1 adenosine receptors induces anxiolytic‐like behaviour, while the activation of A2 sites causes locomotor depression and reduces the effects of A1 receptor activation. The absence of any effect of CPX alone suggests that the receptors involved in modulating behaviour in the elevated plus‐maze in mice are not activated tonically by endogenous adenosine. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

Anxiolytic activity of adenosine receptor activation in mice

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Publisher
Wiley
Copyright
1995 British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
DOI
10.1111/j.1476-5381.1995.tb16421.x
Publisher site
See Article on Publisher Site

Abstract

1 Purine analogues have been examined for anxiolytic‐ and anxiogenic‐like activity in mice, by use of the elevated plus‐maze. 2 The selective A1 receptor agonist, N6‐cyclopentyladenosine (CPA) had marked anxiolytic‐like activity at 10 and 50 μ kg−1, with no effect on locomotor performance at these doses. 3 The A1 selective adenosine receptor antagonist, 1,3‐dipropyl‐8‐cyclopentylxanthine (CPX) had no significant effect on anxiety‐related measures or locomotor behaviour, but blocked the anxiolytic‐like activity of CPA. The hydrophilk xanthine, 8‐(p‐sulphophenyl) theophylline did not prevent anxiolysis by CPA. 4 Caffeine had anxiogenic‐like activity at 30 mg kg−1 which was prevented by CPA at 50 μg kg−1. 5 The A2 receptor agonist, N6‐(2‐(3,5‐dimethoxyphenyl)‐2‐(2‐methylphenyl)‐ethyl)adenosine (DPMA) had no effect on anxiety behaviour but depressed locomotor activity at the highest dose tested of 1 mg kg−1. The A2 receptor antagonist, 1,3‐dimethyl‐l‐propargylxanthine (DMPX) had no effect on anxiety‐related measures or locomotion and did not modify the anxiolytic‐like activity of CPA. 6 Administration of DPMA in combination with anxiolytic doses of CPA prevented the anxiolytic‐like activity of the latter. 7 The results suggest that the selective activation of central A1 adenosine receptors induces anxiolytic‐like behaviour, while the activation of A2 sites causes locomotor depression and reduces the effects of A1 receptor activation. The absence of any effect of CPX alone suggests that the receptors involved in modulating behaviour in the elevated plus‐maze in mice are not activated tonically by endogenous adenosine.

Journal

British Journal of PharmacologyWiley

Published: Oct 1, 1995

References

  • Antagonism of the anti‐conflict effects of phenobarbital, but not diazepam, by the A‐ 1 adenosine agonist 1‐PIA
    COMMISSARIS, COMMISSARIS; MCCLOSKEY, MCCLOSKEY; DAMIAN, DAMIAN; BROWN, BROWN; BARRACO, BARRACO; ALTMAN, ALTMAN
  • Inhibitory and excitatory effects of adenosine receptor agonists on evoked transmitter release from phrenic nerve endings of the rat
    CORREIADESA, CORREIADESA; SEBASTIAO, SEBASTIAO; RIBEIRO, RIBEIRO
  • Adenosine receptor mediated modulation of acetylcholine release from rat striatal synaptosomes
    KIRKPATRICK, KIRKPATRICK; RICHARDSON, RICHARDSON
  • The use of a plus‐maze to measure anxiety in the mouse
    LISTER, LISTER
  • Caffeine and diazepam: separate and combined effects on mood, memory and psychomotor performance
    LOKE, LOKE; HINRICHS, HINRICHS; GHONHEIM, GHONHEIM
  • Excitatory transmitter amino acid release from the ischemic rat cerebral cortex: effects of adenosine receptor agonists and antagonists
    SIMPSON, SIMPSON; O'REGAN, O'REGAN; PERKINS, PERKINS; PHILLIS, PHILLIS
  • Influences of different adenosine receptor subtypes on catalepsy in mice
    ZARRINDAST, ZARRINDAST; MODABBER, MODABBER; SABETKASAI, SABETKASAI

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