The defatted fractions of the Faramea hyacinthina and F. truncata (Rubiaceae) leaf MeOH extracts showed in vitro non‐cytotoxic and anti‐dengue virus serotype 2 (DENV2) activity in human hepatocarcinoma cell lineage (HepG2). Submitting these fractions to the developed RP‐SPE method allowed isolating the antiviral flavanone (2S)‐isosakuranetin‐7‐O‐β‐d‐apiofuranosyl‐(1→6)‐β‐d‐glucopyranoside (1) from both species and yielded less active sub‐fractions. The new diastereoisomeric epimer pair (2S) + (2R) of 5,3′,5′‐trihydroxyflavanone‐7‐O‐β‐d‐apiofuranosyl‐(1→6)‐β‐d‐glucopyranoside (2a/2b) from F. hyacinthina; the known narigenin‐7‐O‐β‐d‐apiofuranosyl‐(1→6)‐β‐d‐glucopyranoside (3) from both species; rutin (4) and quercetin‐4′‐β‐d‐O‐glucopyranosyl‐3‐O‐rutinoside (5) from F. hyacinthina, and kaempferol‐3‐O‐rutinoside (6), erythroxyloside A (7) and asperuloside (8) from F. truncata have been isolated from these sub‐fractions. Compounds 4 – 8 are reported for the first time in Faramea spp.
Chemistry & Biodiversity – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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