Antiviral Activity of Faramea hyacinthina and Faramea truncata Leaves on Dengue Virus Type‐2 and Their Major Compounds

Antiviral Activity of Faramea hyacinthina and Faramea truncata Leaves on Dengue Virus Type‐2... The defatted fractions of the Faramea hyacinthina and F. truncata (Rubiaceae) leaf MeOH extracts showed in vitro non‐cytotoxic and anti‐dengue virus serotype 2 (DENV2) activity in human hepatocarcinoma cell lineage (HepG2). Submitting these fractions to the developed RP‐SPE method allowed isolating the antiviral flavanone (2S)‐isosakuranetin‐7‐O‐β‐d‐apiofuranosyl‐(1→6)‐β‐d‐glucopyranoside (1) from both species and yielded less active sub‐fractions. The new diastereoisomeric epimer pair (2S) + (2R) of 5,3′,5′‐trihydroxyflavanone‐7‐O‐β‐d‐apiofuranosyl‐(1→6)‐β‐d‐glucopyranoside (2a/2b) from F. hyacinthina; the known narigenin‐7‐O‐β‐d‐apiofuranosyl‐(1→6)‐β‐d‐glucopyranoside (3) from both species; rutin (4) and quercetin‐4′‐β‐d‐O‐glucopyranosyl‐3‐O‐rutinoside (5) from F. hyacinthina, and kaempferol‐3‐O‐rutinoside (6), erythroxyloside A (7) and asperuloside (8) from F. truncata have been isolated from these sub‐fractions. Compounds 4 – 8 are reported for the first time in Faramea spp. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chemistry & Biodiversity Wiley

Antiviral Activity of Faramea hyacinthina and Faramea truncata Leaves on Dengue Virus Type‐2 and Their Major Compounds

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Publisher
Wiley
Copyright
© 2018 Wiley‐VHCA AG, Zurich, Switzerland
ISSN
1612-1872
eISSN
1612-1880
D.O.I.
10.1002/cbdv.201700393
Publisher site
See Article on Publisher Site

Abstract

The defatted fractions of the Faramea hyacinthina and F. truncata (Rubiaceae) leaf MeOH extracts showed in vitro non‐cytotoxic and anti‐dengue virus serotype 2 (DENV2) activity in human hepatocarcinoma cell lineage (HepG2). Submitting these fractions to the developed RP‐SPE method allowed isolating the antiviral flavanone (2S)‐isosakuranetin‐7‐O‐β‐d‐apiofuranosyl‐(1→6)‐β‐d‐glucopyranoside (1) from both species and yielded less active sub‐fractions. The new diastereoisomeric epimer pair (2S) + (2R) of 5,3′,5′‐trihydroxyflavanone‐7‐O‐β‐d‐apiofuranosyl‐(1→6)‐β‐d‐glucopyranoside (2a/2b) from F. hyacinthina; the known narigenin‐7‐O‐β‐d‐apiofuranosyl‐(1→6)‐β‐d‐glucopyranoside (3) from both species; rutin (4) and quercetin‐4′‐β‐d‐O‐glucopyranosyl‐3‐O‐rutinoside (5) from F. hyacinthina, and kaempferol‐3‐O‐rutinoside (6), erythroxyloside A (7) and asperuloside (8) from F. truncata have been isolated from these sub‐fractions. Compounds 4 – 8 are reported for the first time in Faramea spp.

Journal

Chemistry & BiodiversityWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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