INTRODUCTIONArenaviruses are enveloped viruses containing a bisegmented single‐stranded RNA genome with an ambisense coding strategy that express four primary viral proteins: the RNA‐dependent RNA polymerase L, the matrix protein Z, the nucleoprotein NP, and the glycoprotein precursor GPC, post‐translationally cleaved to yield the mature virion glycoproteins. Several arenaviruses cause hemorrhagic fevers (HF) with significant level of morbidity and mortality. Among pathogenic arenaviruses, Lassa virus (LASV) and Junín virus (JUNV) are at present the main threat for public health since they generate annual outbreaks of Lassa fever and AHF in endemic areas of West Africa and Argentina, respectively.No specific and safe chemotherapy for any arenavirus is currently available. Treatment is limited to the use of immune convalescent plasma with defined doses of JUNV neutralizing antibodies for AHF or the guanosine analog ribavirin, effective against several RNA viruses including LASV. However, several drawbacks are associated to both treatments, such as failure in advanced infections and undesirable side effects. Then, there is a real need of novel therapeutic options against arenaviruses.In the search of effective and safe antiviral agents, the consideration of host factors involved in virus replication that are known or predicted to bind to a drug as therapeutic targets has
Journal of Medical Virology – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ; ;
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera