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Antidepressants and quality of life in patients with major depressive disorder – Systematic review and meta‐analysis of double‐blind, placebo‐controlled RCTs

Antidepressants and quality of life in patients with major depressive disorder – Systematic... SummationsAntidepressant drug treatment positively affects QoL among patients with an episode of major depressive disorder, but only to a modest extent.Treatment effects on QoL and depression are highly correlated, probably because concepts overlap.Even though social functioning and depression also share certain domains, social functioning may be a more informative part of QoL to target in RCTs of patients with major depressive disorder.LimitationsWhile all scales included in this analysis converge on patient well‐being, QoL is a heterogeneous construct.All results are based on study‐level, not individual patient data.INTRODUCTIONQuality of life has become a key criterion in evaluating treatment success in medicine although it found its way into psychiatry only relatively late.1,2 Today, however, QoL is a common secondary outcome in many RCTs of psychiatric pharmacotherapy, including antidepressant drug trials. Antidepressant efficacy and quality of life share common domains: SF‐36,3 probably the most widespread QoL scale, asks participants: „Have you felt so down in the dumps that nothing could cheer you up? “or „Have you felt downhearted and blue? “– questions clearly related to depressed mood items in depression rating scales, for example, item 1 in the Hamilton Rating Scale for Depression, HAM‐D.4 At the same time, quality of life is the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Psychiatrica Scandinavica Wiley

Antidepressants and quality of life in patients with major depressive disorder – Systematic review and meta‐analysis of double‐blind, placebo‐controlled RCTs

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References (82)

Publisher
Wiley
Copyright
© 2023 Wiley & Sons A/S
ISSN
0001-690X
eISSN
1600-0447
DOI
10.1111/acps.13541
Publisher site
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Abstract

SummationsAntidepressant drug treatment positively affects QoL among patients with an episode of major depressive disorder, but only to a modest extent.Treatment effects on QoL and depression are highly correlated, probably because concepts overlap.Even though social functioning and depression also share certain domains, social functioning may be a more informative part of QoL to target in RCTs of patients with major depressive disorder.LimitationsWhile all scales included in this analysis converge on patient well‐being, QoL is a heterogeneous construct.All results are based on study‐level, not individual patient data.INTRODUCTIONQuality of life has become a key criterion in evaluating treatment success in medicine although it found its way into psychiatry only relatively late.1,2 Today, however, QoL is a common secondary outcome in many RCTs of psychiatric pharmacotherapy, including antidepressant drug trials. Antidepressant efficacy and quality of life share common domains: SF‐36,3 probably the most widespread QoL scale, asks participants: „Have you felt so down in the dumps that nothing could cheer you up? “or „Have you felt downhearted and blue? “– questions clearly related to depressed mood items in depression rating scales, for example, item 1 in the Hamilton Rating Scale for Depression, HAM‐D.4 At the same time, quality of life is the

Journal

Acta Psychiatrica Scandinavica – Wiley

Published: Jun 1, 2023

Keywords: antidepressives; meta analysis; quality of life; randomized controlled trial

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