Dear Editor,We recently presented a case series of seven children who developed severe and complicated Guillain‐Barré syndrome (GBS) after infection with Mycoplasma pneumoniae (Mp) (Meyer Sauteur et al., ). The disease was rapidly progressive and severe: one died, four had clinically defined central nervous system (CNS) involvement, and five required mechanical ventilation. Given the often relatively benign disease course of GBS after this specific type of infection (Meyer Sauteur et al., ) the severe and complicated GBS in this series was rather unexpected. As we recently demonstrated that pediatric and adult GBS after Mp infection is associated with antibodies against galactocerebroside (GalC) (Meyer Sauteur et al., ) we investigated if anti‐GalC antibodies were also present in these children with severe GBS.Sera were tested for immunoglobulin (Ig)M and IgG antibodies to GM1, GM2, GD1a, GD1b, GQ1b, and GalC (all from Sigma–Aldrich, Zwijndrecht, The Netherlands) as previously described (Ang et al., ; Kuijf et al., ; Meyer Sauteur et al., ). Cerebrospinal fluid (CSF) was tested for IgM and IgG to GalC at 1:10 dilution. Optical densities (ODs) at 490 nm from uncoated wells (containing ethanol) were subtracted from glycolipid‐coated wells. Cut‐off values (0.05 for IgG and 0.03 for IgM) were
Journal of the Peripheral Nervous System – Wiley
Published: Jan 1, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.
All for just $49/month
Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.
Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.
It’s easy to organize your research with our built-in tools.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera