Anti‐inflammatory and antioxidant properties of Schisandrin C promote mitochondrial biogenesis in human dental pulp cells

Anti‐inflammatory and antioxidant properties of Schisandrin C promote mitochondrial biogenesis... IntroductionSchisandrin chinensis (Turcz.) also known as ‘Baill.’ is used as a medicinal plant in modern Chinese medicine and as a tonic supplement in the Republic of Korea. Schisandrin C is one of the natural compounds extracted from Schisandra chinensis (Panossian & Wikman ). Its anti‐inflammatory properties inhibit LPS‐induced proinflammatory cytokine and NO production by blocking the MAP kinase pathway in macrophages (Oh et al. ). It also showed antineuroinflammatory effects by increasing antioxidant enzymes in microglia (Park et al. ). Previous study further demonstrated that Schisandrin upregulates haem oxygenase‐1 (HO‐1) through Akt and nuclear factor erythroid 2‐related factor‐2 (Nrf‐2) signalling pathways, which mediate its anti‐inflammatory activities (Park et al. ).Irritation of the dental pulp by bacterial stimuli initiates inflammatory processes and proinflammatory cytokine production. If such irritation lasts for a long time, the tissue will be injured because its healing capacity is overwhelmed (Jain & Gupta ). LPS is one of the bacterial components that cause pulpitis by which matrix metalloproteinase‐2 and ‐9 (MMP‐2/9), intracellular adhesion molecule‐1 (ICAM‐1), vascular cell adhesion molecule‐1 (VCAM‐1) and many cytokines are stimulated (Kim et al. ). Oxidative stress induces apoptosis of pulp cells resulting in an inability to proliferate to replace injured odontoblasts (Lee et al. ). Consequently, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Endodontic Journal Wiley

Anti‐inflammatory and antioxidant properties of Schisandrin C promote mitochondrial biogenesis in human dental pulp cells

Loading next page...
 
/lp/wiley/anti-inflammatory-and-antioxidant-properties-of-schisandrin-c-promote-VlNC74uTo3
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 International Endodontic Journal. Published by John Wiley & Sons Ltd
ISSN
0143-2885
eISSN
1365-2591
D.O.I.
10.1111/iej.12861
Publisher site
See Article on Publisher Site

Abstract

IntroductionSchisandrin chinensis (Turcz.) also known as ‘Baill.’ is used as a medicinal plant in modern Chinese medicine and as a tonic supplement in the Republic of Korea. Schisandrin C is one of the natural compounds extracted from Schisandra chinensis (Panossian & Wikman ). Its anti‐inflammatory properties inhibit LPS‐induced proinflammatory cytokine and NO production by blocking the MAP kinase pathway in macrophages (Oh et al. ). It also showed antineuroinflammatory effects by increasing antioxidant enzymes in microglia (Park et al. ). Previous study further demonstrated that Schisandrin upregulates haem oxygenase‐1 (HO‐1) through Akt and nuclear factor erythroid 2‐related factor‐2 (Nrf‐2) signalling pathways, which mediate its anti‐inflammatory activities (Park et al. ).Irritation of the dental pulp by bacterial stimuli initiates inflammatory processes and proinflammatory cytokine production. If such irritation lasts for a long time, the tissue will be injured because its healing capacity is overwhelmed (Jain & Gupta ). LPS is one of the bacterial components that cause pulpitis by which matrix metalloproteinase‐2 and ‐9 (MMP‐2/9), intracellular adhesion molecule‐1 (ICAM‐1), vascular cell adhesion molecule‐1 (VCAM‐1) and many cytokines are stimulated (Kim et al. ). Oxidative stress induces apoptosis of pulp cells resulting in an inability to proliferate to replace injured odontoblasts (Lee et al. ). Consequently,

Journal

International Endodontic JournalWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off