Anti‐inflammatory and antioxidant properties of Schisandrin C promote mitochondrial biogenesis in human dental pulp cells

Anti‐inflammatory and antioxidant properties of Schisandrin C promote mitochondrial biogenesis... IntroductionSchisandrin chinensis (Turcz.) also known as ‘Baill.’ is used as a medicinal plant in modern Chinese medicine and as a tonic supplement in the Republic of Korea. Schisandrin C is one of the natural compounds extracted from Schisandra chinensis (Panossian & Wikman ). Its anti‐inflammatory properties inhibit LPS‐induced proinflammatory cytokine and NO production by blocking the MAP kinase pathway in macrophages (Oh et al. ). It also showed antineuroinflammatory effects by increasing antioxidant enzymes in microglia (Park et al. ). Previous study further demonstrated that Schisandrin upregulates haem oxygenase‐1 (HO‐1) through Akt and nuclear factor erythroid 2‐related factor‐2 (Nrf‐2) signalling pathways, which mediate its anti‐inflammatory activities (Park et al. ).Irritation of the dental pulp by bacterial stimuli initiates inflammatory processes and proinflammatory cytokine production. If such irritation lasts for a long time, the tissue will be injured because its healing capacity is overwhelmed (Jain & Gupta ). LPS is one of the bacterial components that cause pulpitis by which matrix metalloproteinase‐2 and ‐9 (MMP‐2/9), intracellular adhesion molecule‐1 (ICAM‐1), vascular cell adhesion molecule‐1 (VCAM‐1) and many cytokines are stimulated (Kim et al. ). Oxidative stress induces apoptosis of pulp cells resulting in an inability to proliferate to replace injured odontoblasts (Lee et al. ). Consequently, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Endodontic Journal Wiley

Anti‐inflammatory and antioxidant properties of Schisandrin C promote mitochondrial biogenesis in human dental pulp cells

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 International Endodontic Journal. Published by John Wiley & Sons Ltd
ISSN
0143-2885
eISSN
1365-2591
D.O.I.
10.1111/iej.12861
Publisher site
See Article on Publisher Site

Abstract

IntroductionSchisandrin chinensis (Turcz.) also known as ‘Baill.’ is used as a medicinal plant in modern Chinese medicine and as a tonic supplement in the Republic of Korea. Schisandrin C is one of the natural compounds extracted from Schisandra chinensis (Panossian & Wikman ). Its anti‐inflammatory properties inhibit LPS‐induced proinflammatory cytokine and NO production by blocking the MAP kinase pathway in macrophages (Oh et al. ). It also showed antineuroinflammatory effects by increasing antioxidant enzymes in microglia (Park et al. ). Previous study further demonstrated that Schisandrin upregulates haem oxygenase‐1 (HO‐1) through Akt and nuclear factor erythroid 2‐related factor‐2 (Nrf‐2) signalling pathways, which mediate its anti‐inflammatory activities (Park et al. ).Irritation of the dental pulp by bacterial stimuli initiates inflammatory processes and proinflammatory cytokine production. If such irritation lasts for a long time, the tissue will be injured because its healing capacity is overwhelmed (Jain & Gupta ). LPS is one of the bacterial components that cause pulpitis by which matrix metalloproteinase‐2 and ‐9 (MMP‐2/9), intracellular adhesion molecule‐1 (ICAM‐1), vascular cell adhesion molecule‐1 (VCAM‐1) and many cytokines are stimulated (Kim et al. ). Oxidative stress induces apoptosis of pulp cells resulting in an inability to proliferate to replace injured odontoblasts (Lee et al. ). Consequently,

Journal

International Endodontic JournalWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

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