Anti‐D reagents should be chosen accordingly to the prevalence of D variants in the obstetric population

Anti‐D reagents should be chosen accordingly to the prevalence of D variants in the obstetric... INTRODUCTIONThe RhD antigen is clinically the most significant blood group antigen for obstetric medicine due to its immunogenicity and the high incidence of RhD‐ individuals. Depending on the population, 3%‐25% of Caucasians are D−, with 15%‐20% prevalence being most commonly reported. Anti‐D is still the leading cause of the hemolytic disease of fetus and newborn (HDFN) in the obstetric population of Split‐Dalmatian County, Croatia.The division between D+ and D− status is not always straightforward, due to over 200 D variant phenotypes having been reported to date. Generally, “weak D” variants are result of mutations in which all D epitopes are present but with reduced expression, while “partial D” represents variants in which the mutations result in the absence of certain polypeptides on the outer RBC surface. Recent research found weak D types to also possess slightly to considerably altered D antigens, with the extent of qualitative changes overlapping with that in partial D. The prevalence of weak D types among Caucasians is reported to be about 0.2%‐1%. Most weak D variants in Caucasians are weak D type 1, type 2 and type 3 (RHD*weak D type 1, RHD*weak D type 2, RHD*weak D type 3, which are not known http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Laboratory Analysis Wiley

Anti‐D reagents should be chosen accordingly to the prevalence of D variants in the obstetric population

Loading next page...
 
/lp/wiley/anti-d-reagents-should-be-chosen-accordingly-to-the-prevalence-of-d-VmJXUCGRtA
Publisher
Wiley
Copyright
Copyright © 2018 Wiley Periodicals, Inc.
ISSN
0887-8013
eISSN
1098-2825
D.O.I.
10.1002/jcla.22285
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONThe RhD antigen is clinically the most significant blood group antigen for obstetric medicine due to its immunogenicity and the high incidence of RhD‐ individuals. Depending on the population, 3%‐25% of Caucasians are D−, with 15%‐20% prevalence being most commonly reported. Anti‐D is still the leading cause of the hemolytic disease of fetus and newborn (HDFN) in the obstetric population of Split‐Dalmatian County, Croatia.The division between D+ and D− status is not always straightforward, due to over 200 D variant phenotypes having been reported to date. Generally, “weak D” variants are result of mutations in which all D epitopes are present but with reduced expression, while “partial D” represents variants in which the mutations result in the absence of certain polypeptides on the outer RBC surface. Recent research found weak D types to also possess slightly to considerably altered D antigens, with the extent of qualitative changes overlapping with that in partial D. The prevalence of weak D types among Caucasians is reported to be about 0.2%‐1%. Most weak D variants in Caucasians are weak D type 1, type 2 and type 3 (RHD*weak D type 1, RHD*weak D type 2, RHD*weak D type 3, which are not known

Journal

Journal of Clinical Laboratory AnalysisWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off