Anti‐D reagents should be chosen accordingly to the prevalence of D variants in the obstetric population

Anti‐D reagents should be chosen accordingly to the prevalence of D variants in the obstetric... INTRODUCTIONThe RhD antigen is clinically the most significant blood group antigen for obstetric medicine due to its immunogenicity and the high incidence of RhD‐ individuals. Depending on the population, 3%‐25% of Caucasians are D−, with 15%‐20% prevalence being most commonly reported. Anti‐D is still the leading cause of the hemolytic disease of fetus and newborn (HDFN) in the obstetric population of Split‐Dalmatian County, Croatia.The division between D+ and D− status is not always straightforward, due to over 200 D variant phenotypes having been reported to date. Generally, “weak D” variants are result of mutations in which all D epitopes are present but with reduced expression, while “partial D” represents variants in which the mutations result in the absence of certain polypeptides on the outer RBC surface. Recent research found weak D types to also possess slightly to considerably altered D antigens, with the extent of qualitative changes overlapping with that in partial D. The prevalence of weak D types among Caucasians is reported to be about 0.2%‐1%. Most weak D variants in Caucasians are weak D type 1, type 2 and type 3 (RHD*weak D type 1, RHD*weak D type 2, RHD*weak D type 3, which are not known http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Laboratory Analysis Wiley

Anti‐D reagents should be chosen accordingly to the prevalence of D variants in the obstetric population

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 Wiley Periodicals, Inc.
ISSN
0887-8013
eISSN
1098-2825
D.O.I.
10.1002/jcla.22285
Publisher site
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Abstract

INTRODUCTIONThe RhD antigen is clinically the most significant blood group antigen for obstetric medicine due to its immunogenicity and the high incidence of RhD‐ individuals. Depending on the population, 3%‐25% of Caucasians are D−, with 15%‐20% prevalence being most commonly reported. Anti‐D is still the leading cause of the hemolytic disease of fetus and newborn (HDFN) in the obstetric population of Split‐Dalmatian County, Croatia.The division between D+ and D− status is not always straightforward, due to over 200 D variant phenotypes having been reported to date. Generally, “weak D” variants are result of mutations in which all D epitopes are present but with reduced expression, while “partial D” represents variants in which the mutations result in the absence of certain polypeptides on the outer RBC surface. Recent research found weak D types to also possess slightly to considerably altered D antigens, with the extent of qualitative changes overlapping with that in partial D. The prevalence of weak D types among Caucasians is reported to be about 0.2%‐1%. Most weak D variants in Caucasians are weak D type 1, type 2 and type 3 (RHD*weak D type 1, RHD*weak D type 2, RHD*weak D type 3, which are not known

Journal

Journal of Clinical Laboratory AnalysisWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

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