Antenatal diagnosis and palliative treatment of non‐immune hydrops fetalis secondary to fetal parvovirus B19 infection

Antenatal diagnosis and palliative treatment of non‐immune hydrops fetalis secondary to fetal... Hydrops fetalis was diagnosed at 22 weeks. An ultrasound examination demonstrated cardiomegaly and a fetal blood specimen obtained by cordocentesis revealed thrombocytopenia, anaemia, and neutropenia. Fetal paracentesis yielded straw‐coloured fluid with electrolytes indicative of a transudate. Non‐enveloped icosahedral viral particles approximately 23 mm in diameter were visualized in the ascitic fluid by electron microscopy. Immune electron microscopy confirmed human parvovirus B19. Direct fetal digitalization led to a reduction in umbilical artery resistance, a decline in the abdominal circumference from 20·3 to 17·8 cm, and resolution of the ascites within 72 h. Despite this dramatic response to therapy, fetal death occurred on day 5 of treatment. The initial maternal serum was positive for anti‐B19 IgM and IgG antibodies. Electron microscopy of fetal cardiac tissue obtained post‐mortem revealed intranuclear viral particles typical of B19, confirming the antenatal diagnosis of myocarditis. This case demonstrates that direct viral identification is applicable to prenatal diagnosis. To our knowledge, this is the first reported case of the antenatal diagnosis and palliative treatment of fetal viral infection. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Prenatal Diagnosis Wiley

Antenatal diagnosis and palliative treatment of non‐immune hydrops fetalis secondary to fetal parvovirus B19 infection

Prenatal Diagnosis, Volume 9 (2) – Feb 1, 1989

Loading next page...
 
/lp/wiley/antenatal-diagnosis-and-palliative-treatment-of-non-immune-hydrops-cx3jIS6TSo
Publisher
Wiley
Copyright
Copyright © 1989 John Wiley & Sons, Ltd.
ISSN
0197-3851
eISSN
1097-0223
DOI
10.1002/pd.1970090205
Publisher site
See Article on Publisher Site

Abstract

Hydrops fetalis was diagnosed at 22 weeks. An ultrasound examination demonstrated cardiomegaly and a fetal blood specimen obtained by cordocentesis revealed thrombocytopenia, anaemia, and neutropenia. Fetal paracentesis yielded straw‐coloured fluid with electrolytes indicative of a transudate. Non‐enveloped icosahedral viral particles approximately 23 mm in diameter were visualized in the ascitic fluid by electron microscopy. Immune electron microscopy confirmed human parvovirus B19. Direct fetal digitalization led to a reduction in umbilical artery resistance, a decline in the abdominal circumference from 20·3 to 17·8 cm, and resolution of the ascites within 72 h. Despite this dramatic response to therapy, fetal death occurred on day 5 of treatment. The initial maternal serum was positive for anti‐B19 IgM and IgG antibodies. Electron microscopy of fetal cardiac tissue obtained post‐mortem revealed intranuclear viral particles typical of B19, confirming the antenatal diagnosis of myocarditis. This case demonstrates that direct viral identification is applicable to prenatal diagnosis. To our knowledge, this is the first reported case of the antenatal diagnosis and palliative treatment of fetal viral infection.

Journal

Prenatal DiagnosisWiley

Published: Feb 1, 1989

References

  • Intrauterine infection with human parvovirus
    Bond, Bond; Caul, Caul; Usher, Usher; Cohen, Cohen; Clewley, Clewley; Field, Field
  • Detection of parvovirus B19 DNA, antigen and particles in the human fetus
    Clewley, Clewley; Cohen, Cohen; Field, Field
  • Acute and chronic canine parvovirus myocarditis following intrauterine inoculation
    Lenghaus, Lenghaus; Studdert, Studdert; Finnie, Finnie
  • Human parvovirus and the fetus
    Mortimer, Mortimer; Cohen, Cohen; Buckely, Buckely; Cradock‐Watson, Cradock‐Watson; Ridehalgh, Ridehalgh; Burkhardt, Burkhardt; Schilt, Schilt
  • Erythema infectiosum (fifth disease) occurrence in Iowa
    Naides, Naides

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off