Angiosarcoma following treatment of basal cell carcinoma: a report of two cases

Angiosarcoma following treatment of basal cell carcinoma: a report of two cases Cutaneous angiosarcoma (CAS) is an uncommon malignant neoplasm of vascular or lymphatic origin accounting for less than 1% of all sarcomas. The neoplasm typically manifests as a diffuse bruise‐like lesion or an elevated nodule, with occasional ulceration and bleeding. Lesions commonly favor the head and neck in elderly men. On rare occasions, CAS may also occur around foreign objects, neoplasms, and surgically created sites. Herein, we describe two unique presentations of CAS arising within previous basal cell carcinoma (BCC) surgical sites.The first patient is an 81‐year‐old Caucasian man who presented 9 months after having Mohs micrographic surgery (MMS) for a BCC on the left lateral eyebrow (Fig. a) with a purpuric plaque extending from his left forehead onto his left face with an erythematous indurated leading margin and multiple raised, tender tumors on his temporal scalp (Fig. b). Punch biopsy revealed an atypical vascular proliferation of dilated and slit‐like spaces lined by hyperchromatic and pleomorphic endothelial cells with surrounding red blood cell extravasation (Fig. c). A CD31 immunostain highlighted the vessel lumens and confirmed an infiltrative growth pattern in the superficial dermis (Fig. d). These findings were consistent with a diagnosis of well‐differentiated angiosarcoma, extending to peripheral margins.(a) Patient http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Dermatology Wiley

Angiosarcoma following treatment of basal cell carcinoma: a report of two cases

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Publisher
Wiley
Copyright
International Journal of Dermatology © 2018 International Society of Dermatology
ISSN
0011-9059
eISSN
1365-4632
D.O.I.
10.1111/ijd.13908
Publisher site
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Abstract

Cutaneous angiosarcoma (CAS) is an uncommon malignant neoplasm of vascular or lymphatic origin accounting for less than 1% of all sarcomas. The neoplasm typically manifests as a diffuse bruise‐like lesion or an elevated nodule, with occasional ulceration and bleeding. Lesions commonly favor the head and neck in elderly men. On rare occasions, CAS may also occur around foreign objects, neoplasms, and surgically created sites. Herein, we describe two unique presentations of CAS arising within previous basal cell carcinoma (BCC) surgical sites.The first patient is an 81‐year‐old Caucasian man who presented 9 months after having Mohs micrographic surgery (MMS) for a BCC on the left lateral eyebrow (Fig. a) with a purpuric plaque extending from his left forehead onto his left face with an erythematous indurated leading margin and multiple raised, tender tumors on his temporal scalp (Fig. b). Punch biopsy revealed an atypical vascular proliferation of dilated and slit‐like spaces lined by hyperchromatic and pleomorphic endothelial cells with surrounding red blood cell extravasation (Fig. c). A CD31 immunostain highlighted the vessel lumens and confirmed an infiltrative growth pattern in the superficial dermis (Fig. d). These findings were consistent with a diagnosis of well‐differentiated angiosarcoma, extending to peripheral margins.(a) Patient

Journal

International Journal of DermatologyWiley

Published: Jan 1, 2018

References

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