Angiosarcoma following treatment of basal cell carcinoma: a report of two cases

Angiosarcoma following treatment of basal cell carcinoma: a report of two cases Cutaneous angiosarcoma (CAS) is an uncommon malignant neoplasm of vascular or lymphatic origin accounting for less than 1% of all sarcomas. The neoplasm typically manifests as a diffuse bruise‐like lesion or an elevated nodule, with occasional ulceration and bleeding. Lesions commonly favor the head and neck in elderly men. On rare occasions, CAS may also occur around foreign objects, neoplasms, and surgically created sites. Herein, we describe two unique presentations of CAS arising within previous basal cell carcinoma (BCC) surgical sites.The first patient is an 81‐year‐old Caucasian man who presented 9 months after having Mohs micrographic surgery (MMS) for a BCC on the left lateral eyebrow (Fig. a) with a purpuric plaque extending from his left forehead onto his left face with an erythematous indurated leading margin and multiple raised, tender tumors on his temporal scalp (Fig. b). Punch biopsy revealed an atypical vascular proliferation of dilated and slit‐like spaces lined by hyperchromatic and pleomorphic endothelial cells with surrounding red blood cell extravasation (Fig. c). A CD31 immunostain highlighted the vessel lumens and confirmed an infiltrative growth pattern in the superficial dermis (Fig. d). These findings were consistent with a diagnosis of well‐differentiated angiosarcoma, extending to peripheral margins.(a) Patient http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Dermatology Wiley

Angiosarcoma following treatment of basal cell carcinoma: a report of two cases

Loading next page...
 
/lp/wiley/angiosarcoma-following-treatment-of-basal-cell-carcinoma-a-report-of-X6vFHBqG2o
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
International Journal of Dermatology © 2018 International Society of Dermatology
ISSN
0011-9059
eISSN
1365-4632
D.O.I.
10.1111/ijd.13908
Publisher site
See Article on Publisher Site

Abstract

Cutaneous angiosarcoma (CAS) is an uncommon malignant neoplasm of vascular or lymphatic origin accounting for less than 1% of all sarcomas. The neoplasm typically manifests as a diffuse bruise‐like lesion or an elevated nodule, with occasional ulceration and bleeding. Lesions commonly favor the head and neck in elderly men. On rare occasions, CAS may also occur around foreign objects, neoplasms, and surgically created sites. Herein, we describe two unique presentations of CAS arising within previous basal cell carcinoma (BCC) surgical sites.The first patient is an 81‐year‐old Caucasian man who presented 9 months after having Mohs micrographic surgery (MMS) for a BCC on the left lateral eyebrow (Fig. a) with a purpuric plaque extending from his left forehead onto his left face with an erythematous indurated leading margin and multiple raised, tender tumors on his temporal scalp (Fig. b). Punch biopsy revealed an atypical vascular proliferation of dilated and slit‐like spaces lined by hyperchromatic and pleomorphic endothelial cells with surrounding red blood cell extravasation (Fig. c). A CD31 immunostain highlighted the vessel lumens and confirmed an infiltrative growth pattern in the superficial dermis (Fig. d). These findings were consistent with a diagnosis of well‐differentiated angiosarcoma, extending to peripheral margins.(a) Patient

Journal

International Journal of DermatologyWiley

Published: Jan 1, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial