Anatomical localization and clinical impact of sentinel lymph nodes based on patterns of pelvic lymphatic drainage in clinically localized prostate cancer

Anatomical localization and clinical impact of sentinel lymph nodes based on patterns of pelvic... AbbreviationsePLNDextended pelvic lymph node dissectionICGindocyanine greenLNMlymph node metastasisLRPlaparoscopic radical prostatectomyNIRnear infra‐redNPVnegative predictive valuePLNDpelvic lymph node dissectionPPVpositive predictive valueSLNsentinel lymph nodeINTRODUCTIONLNM in prostate cancer is an unfavorable prognostic factor. Although recent consensus suggests that ePLND offers greater accuracy than standard PLND in detecting occult LNM, debate continues on the optimal anatomical extent and therapeutic benefits of ePLND. The template boundary in ePLND is subjective and variable across institutions or urologists, which could affect the interpretation of available information.The SLN is the first node or group of nodes that drain lymph and thus cancer cells from a tumor, so it can predict the status of the regional nodal basin. Since Wawroschek et al published the first reports of radio‐guided SLN biopsy in prostate cancer in 1999, the SLN has been generating renewed interest. However, its significance remains controversial due to inadequate evidence. Although radiotracers have been used primarily to study SLN in prostate cancer, the fluorescent dye ICG can also be used as a non‐radioactive and nontoxic tracer. Several recent reports of ICG fluorescence imaging guided technique have described the feasibility and safety of its detection in prostate cancer. However, the exact SLN relatedanatomy of lymphatic drainage has not been well http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Prostate Wiley

Anatomical localization and clinical impact of sentinel lymph nodes based on patterns of pelvic lymphatic drainage in clinically localized prostate cancer

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0270-4137
eISSN
1097-0045
D.O.I.
10.1002/pros.23486
Publisher site
See Article on Publisher Site

Abstract

AbbreviationsePLNDextended pelvic lymph node dissectionICGindocyanine greenLNMlymph node metastasisLRPlaparoscopic radical prostatectomyNIRnear infra‐redNPVnegative predictive valuePLNDpelvic lymph node dissectionPPVpositive predictive valueSLNsentinel lymph nodeINTRODUCTIONLNM in prostate cancer is an unfavorable prognostic factor. Although recent consensus suggests that ePLND offers greater accuracy than standard PLND in detecting occult LNM, debate continues on the optimal anatomical extent and therapeutic benefits of ePLND. The template boundary in ePLND is subjective and variable across institutions or urologists, which could affect the interpretation of available information.The SLN is the first node or group of nodes that drain lymph and thus cancer cells from a tumor, so it can predict the status of the regional nodal basin. Since Wawroschek et al published the first reports of radio‐guided SLN biopsy in prostate cancer in 1999, the SLN has been generating renewed interest. However, its significance remains controversial due to inadequate evidence. Although radiotracers have been used primarily to study SLN in prostate cancer, the fluorescent dye ICG can also be used as a non‐radioactive and nontoxic tracer. Several recent reports of ICG fluorescence imaging guided technique have described the feasibility and safety of its detection in prostate cancer. However, the exact SLN relatedanatomy of lymphatic drainage has not been well

Journal

The ProstateWiley

Published: Jan 1, 2018

Keywords: ; ;

References

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