Analysis of a zebrafish semaphorin reveals potential functions in vivo

Analysis of a zebrafish semaphorin reveals potential functions in vivo The semaphorin/collapsin gene family is a large and diverse family encoding both secreted and transmembrane proteins, some of which are thought to act as repulsive axon guidance molecules. However, the function of most semaphorins is still unknown. We have cloned and characterized several semaphorins in the zebrafish in order to assess their in vivo function. Zebrafish semaZ2 is expressed in a dynamic and restricted pattern during the period of axon outgrowth that indicates potential roles in the guidance of several axon pathways. Analysis of mutant zebrafish with reduced semaZ2 expression reveals axon pathfinding errors that implicate SemaZ2 in normal guidance. Dev Dyn 1999;214:13–25. © 1999 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Developmental Dynamics Wiley

Analysis of a zebrafish semaphorin reveals potential functions in vivo

Loading next page...
 
/lp/wiley/analysis-of-a-zebrafish-semaphorin-reveals-potential-functions-in-vivo-QwHA8fQkm2
Publisher
Wiley
Copyright
Copyright © 1999 Wiley‐Liss, Inc.
ISSN
1058-8388
eISSN
1097-0177
DOI
10.1002/(SICI)1097-0177(199901)214:1<13::AID-DVDY2>3.0.CO;2-3
Publisher site
See Article on Publisher Site

Abstract

The semaphorin/collapsin gene family is a large and diverse family encoding both secreted and transmembrane proteins, some of which are thought to act as repulsive axon guidance molecules. However, the function of most semaphorins is still unknown. We have cloned and characterized several semaphorins in the zebrafish in order to assess their in vivo function. Zebrafish semaZ2 is expressed in a dynamic and restricted pattern during the period of axon outgrowth that indicates potential roles in the guidance of several axon pathways. Analysis of mutant zebrafish with reduced semaZ2 expression reveals axon pathfinding errors that implicate SemaZ2 in normal guidance. Dev Dyn 1999;214:13–25. © 1999 Wiley‐Liss, Inc.

Journal

Developmental DynamicsWiley

Published: Jan 1, 1999

References

  • Functions of netrins and semaphorins in axon guidance
    Culotti, Culotti; Kolodkin, Kolodkin
  • A novel transmembrane semaphorin can bind c‐src
    Eckhardt, Eckhardt; Behar, Behar; Calautti, Calautti; Yonezawa, Yonezawa; Nishimoto, Nishimoto; Fishman, Fishman
  • Stages of embryonic development of the zebrafish
    Kimmel, Kimmel; Ballard, Ballard; Kimmel, Kimmel; Ullmann, Ullmann; Schilling, Schilling
  • Axon tracts correlate with netrin‐1a expression in the zebrafish embryo
    Lauderdale, Lauderdale; Davis, Davis; Kuwada, Kuwada
  • The sensory innervation of the mouse spinal cord may be patterned by differential expression of and differential responsiveness to semaphorins
    Püschel, Püschel; Adams, Adams; Betz, Betz
  • Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21, a region deleted in lung cancer
    Xiang, Xiang; Hensel, Hensel; Garcia, Garcia; Carlson, Carlson; Kok, Kok; Daly, Daly; Kerbacher, Kerbacher; van den Berg, van den Berg; Veldhuis, Veldhuis; Buys, Buys; Naylor, Naylor
  • Cloning and expression of a novel murine semaphorin with structural similarity to insect semaphorin I
    Zhou, Zhou; White, White; Lentz, Lentz; Wright, Wright; Fisher, Fisher; Snider, Snider

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off