An Italian multicentre study on methylchloroisothiazolinone/methylisothiazolinone contact sensitivity: understanding the structure–activity relationship

An Italian multicentre study on methylchloroisothiazolinone/methylisothiazolinone contact... The mixture methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI) is a well‐known contact sensitizer . However, studies to determine the primary sensitizer in this blend are rare, and have been performed only in small groups of patients (). Herein, we present a larger study on humans in which we used the structure–activity relationship of the molecules to explain (i) why MCI is the stronger allergen, and (ii) why cross‐reactivity between MCI and MI can be expected.Materials and MethodsFrom January 2016 to December 2016, eight patch‐testing Italian clinics conducted a study on 141 patients (34 men and 107 women; mean age 44.1 years) recently found to be sensitized to MCI/MI 0.02% aq. We recalled patients with positive patch test reactions to MCI/MI during the period 2014–2016, mainly resulting from non‐occupational exposure (cosmetics). The patients were patch tested with MCI and MI at the same concentrations as in the blend: MCI 0.015% aq. (provided by the Laboratory of the Department of Occupational and Environmental Dermatology, Lund University, Malmö, Sweden) and MI 0.005% aq. (FIRMA, Florence, Italy). We also tested MI 0.2% aq. (FIRMA) (, ). In this study, micropipettes were used for dosing, and haptens (0.2 ml) were simultaneously applied. Occlusion was performed for 2 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Contact Dermatitis Wiley

An Italian multicentre study on methylchloroisothiazolinone/methylisothiazolinone contact sensitivity: understanding the structure–activity relationship

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
ISSN
0105-1873
eISSN
1600-0536
D.O.I.
10.1111/cod.12935
Publisher site
See Article on Publisher Site

Abstract

The mixture methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI) is a well‐known contact sensitizer . However, studies to determine the primary sensitizer in this blend are rare, and have been performed only in small groups of patients (). Herein, we present a larger study on humans in which we used the structure–activity relationship of the molecules to explain (i) why MCI is the stronger allergen, and (ii) why cross‐reactivity between MCI and MI can be expected.Materials and MethodsFrom January 2016 to December 2016, eight patch‐testing Italian clinics conducted a study on 141 patients (34 men and 107 women; mean age 44.1 years) recently found to be sensitized to MCI/MI 0.02% aq. We recalled patients with positive patch test reactions to MCI/MI during the period 2014–2016, mainly resulting from non‐occupational exposure (cosmetics). The patients were patch tested with MCI and MI at the same concentrations as in the blend: MCI 0.015% aq. (provided by the Laboratory of the Department of Occupational and Environmental Dermatology, Lund University, Malmö, Sweden) and MI 0.005% aq. (FIRMA, Florence, Italy). We also tested MI 0.2% aq. (FIRMA) (, ). In this study, micropipettes were used for dosing, and haptens (0.2 ml) were simultaneously applied. Occlusion was performed for 2

Journal

Contact DermatitisWiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ; ; ; ; ;

References

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