An Italian multicentre study on methylchloroisothiazolinone/methylisothiazolinone contact sensitivity: understanding the structure–activity relationship

An Italian multicentre study on methylchloroisothiazolinone/methylisothiazolinone contact... The mixture methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI) is a well‐known contact sensitizer . However, studies to determine the primary sensitizer in this blend are rare, and have been performed only in small groups of patients (). Herein, we present a larger study on humans in which we used the structure–activity relationship of the molecules to explain (i) why MCI is the stronger allergen, and (ii) why cross‐reactivity between MCI and MI can be expected.Materials and MethodsFrom January 2016 to December 2016, eight patch‐testing Italian clinics conducted a study on 141 patients (34 men and 107 women; mean age 44.1 years) recently found to be sensitized to MCI/MI 0.02% aq. We recalled patients with positive patch test reactions to MCI/MI during the period 2014–2016, mainly resulting from non‐occupational exposure (cosmetics). The patients were patch tested with MCI and MI at the same concentrations as in the blend: MCI 0.015% aq. (provided by the Laboratory of the Department of Occupational and Environmental Dermatology, Lund University, Malmö, Sweden) and MI 0.005% aq. (FIRMA, Florence, Italy). We also tested MI 0.2% aq. (FIRMA) (, ). In this study, micropipettes were used for dosing, and haptens (0.2 ml) were simultaneously applied. Occlusion was performed for 2 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Contact Dermatitis Wiley

An Italian multicentre study on methylchloroisothiazolinone/methylisothiazolinone contact sensitivity: understanding the structure–activity relationship

Loading next page...
 
/lp/wiley/an-italian-multicentre-study-on-methylchloroisothiazolinone-psNnpG9twh
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
ISSN
0105-1873
eISSN
1600-0536
D.O.I.
10.1111/cod.12935
Publisher site
See Article on Publisher Site

Abstract

The mixture methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI) is a well‐known contact sensitizer . However, studies to determine the primary sensitizer in this blend are rare, and have been performed only in small groups of patients (). Herein, we present a larger study on humans in which we used the structure–activity relationship of the molecules to explain (i) why MCI is the stronger allergen, and (ii) why cross‐reactivity between MCI and MI can be expected.Materials and MethodsFrom January 2016 to December 2016, eight patch‐testing Italian clinics conducted a study on 141 patients (34 men and 107 women; mean age 44.1 years) recently found to be sensitized to MCI/MI 0.02% aq. We recalled patients with positive patch test reactions to MCI/MI during the period 2014–2016, mainly resulting from non‐occupational exposure (cosmetics). The patients were patch tested with MCI and MI at the same concentrations as in the blend: MCI 0.015% aq. (provided by the Laboratory of the Department of Occupational and Environmental Dermatology, Lund University, Malmö, Sweden) and MI 0.005% aq. (FIRMA, Florence, Italy). We also tested MI 0.2% aq. (FIRMA) (, ). In this study, micropipettes were used for dosing, and haptens (0.2 ml) were simultaneously applied. Occlusion was performed for 2

Journal

Contact DermatitisWiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ; ; ; ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial