AbbreviationsDSSdisease‐specific survivalEBRTexternal beam radiotherapyESTSextremity soft tissue sarcomaHILPhyperthermic isolated limb perfusionIRBinstitutional review boardIQRinterquartile rangeLRFSlocal recurrence free survivalLSTlimb salvage treatmentMPNSTmalignant peripheral nerve sheath tumorOSoverall survivalSTSsoft tissue sarcomasUMCGUniversity Medical Center GroningenINTRODUCTIONSoft tissue sarcomas (STS) are rare, malignant tumors with an incidence of 12 310 new cases in the United States and 729 in the Netherlands in 2016, resulting in 4990/300 STS related deaths in the United States and in the Netherlands in 2016. STS form a heterogeneous group of tumors including more than 50 different histologic subtypes. The most common subtypes are pleomorphic undifferentiated sarcoma (including malignant fibrous histiocytoma), liposarcoma, leiomyosarcoma, synovial sarcoma, and malignant peripheral nerve sheath tumor, which account for a total of 76% of all STS. STS can occur at any anatomic location but most often arise in the limbs (60‐70%). Despite complete resection, with or without (neo)adjuvant treatment, STS are known for their potential to recur locally and/or to cause distant metastases, mainly to the lungs. The available data considering the improvement of survival following (neo)adjuvant systemic chemotherapy are inconsistent and under on‐going investigation.Amputation does not increase the survival rate of patients with extremity soft tissue sarcoma (ESTS) when compared with limb salvage surgery combined with (postoperative) radiotherapy. So,
Journal of Surgical Oncology – Wiley
Published: Jan 1, 2018
Keywords: ; ;
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