Alzheimer'S disease: Monoamines and spiperone binding reduced in nucleus basalis

Alzheimer'S disease: Monoamines and spiperone binding reduced in nucleus basalis Levels of dopamine and serotonin, and of their precursors and metabolites, were measured in the nucleus basalis of Meynert (nbM) of patients with Alzheimer's disease and control patients. (3H)Spiperone binding to membrane homogenates of the nbM, indicative of both dopaminergic and serotonergic receptors, was also measured. The nbM from patients with Alzheimer's disease showed significant decreases in both spiperone binding and in the levels of dopamine and serotonin but no decrease in either tyrosine or tryptophan levels. These data indicate a loss of both dopaminergic and serotonergic synapses in the nbM of patients with Alzheimer's disease. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Neurology Wiley

Alzheimer'S disease: Monoamines and spiperone binding reduced in nucleus basalis

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Publisher
Wiley
Copyright
Copyright © 1986 American Neurological Association
ISSN
0364-5134
eISSN
1531-8249
DOI
10.1002/ana.410190616
Publisher site
See Article on Publisher Site

Abstract

Levels of dopamine and serotonin, and of their precursors and metabolites, were measured in the nucleus basalis of Meynert (nbM) of patients with Alzheimer's disease and control patients. (3H)Spiperone binding to membrane homogenates of the nbM, indicative of both dopaminergic and serotonergic receptors, was also measured. The nbM from patients with Alzheimer's disease showed significant decreases in both spiperone binding and in the levels of dopamine and serotonin but no decrease in either tyrosine or tryptophan levels. These data indicate a loss of both dopaminergic and serotonergic synapses in the nbM of patients with Alzheimer's disease.

Journal

Annals of NeurologyWiley

Published: Jun 1, 1986

References

  • Biochemical assessment of serotonergic and cholinergic dysfunction and cerebral atrophy in Alzheimer's disease
    Bowen, Bowen; Allen, Allen; Benton, Benton
  • Nucleus raphe dorsalis in Alzheimer's disease: neurofibrillary tangles and loss of large neurons
    Yamamoto, Yamamoto; Hirano, Hirano

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