Altered circadian melatonin secretion patterns in relation to sleep in patients with chronic sleep‐wake rhythm disorders

Altered circadian melatonin secretion patterns in relation to sleep in patients with chronic... Rodenbeck A, Huether G, Rüther E, Hajak G. Altered circadian melatonin secretion patterns in relation to sleep in patients with chronic sleep‐wake rhythm disorders. J. Pineal Res. 1998; 25:201–210. © Munksgaard, Copenhagen Human well‐being depends on the entrainment of endogenous circadian rhythms of biological functions and the sleep‐wake rhythm. Although the incidence of otherwise healthy subjects with chronically altered sleep‐wake rhythms is rather low, the investigation of these patients provides new sights into circadian entrainment mechanisms. We therefore examined the circadian rhythm of circulating melatonin and the sleep‐wake rhythm in five patients with chronic sleep‐wake rhythm disorders and ten age‐matched healthy controls. All patients showed altered circadian melatonin rhythm parameters in relation to their sleep‐wake cycle compared to age‐matched controls. These alterations were random, i.e., independent of the type, the duration, and the age of onset of the disorder. The melatonin onset to sleep onset interval varied between the patients and the melatonin acrophase to sleep offset interval was prolonged in four patients. These findings indicate individual phase relations between the circadian melatonin rhythm and the sleep‐wake cycle in patients with chronic sleep‐wake rhythm disorders. Since the prolonged melatonin acrophase to sleep offset interval was the most consistent finding independent of aetiological origins, this abnormality may be one possible maintaining factor in chronic sleep‐wake rhythm disorders due to reduced phase‐resetting properties of the circadian pacemaker. Furthermore, rather low circadian melatonin amplitudes and a subsensitivity to daylight may maintain the disorder in at least some patients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pineal Research Wiley

Altered circadian melatonin secretion patterns in relation to sleep in patients with chronic sleep‐wake rhythm disorders

Loading next page...
 
/lp/wiley/altered-circadian-melatonin-secretion-patterns-in-relation-to-sleep-in-e5yVTWEhaq
Publisher
Wiley
Copyright
Copyright © 1998 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0742-3098
eISSN
1600-079X
DOI
10.1111/j.1600-079X.1998.tb00389.x
Publisher site
See Article on Publisher Site

Abstract

Rodenbeck A, Huether G, Rüther E, Hajak G. Altered circadian melatonin secretion patterns in relation to sleep in patients with chronic sleep‐wake rhythm disorders. J. Pineal Res. 1998; 25:201–210. © Munksgaard, Copenhagen Human well‐being depends on the entrainment of endogenous circadian rhythms of biological functions and the sleep‐wake rhythm. Although the incidence of otherwise healthy subjects with chronically altered sleep‐wake rhythms is rather low, the investigation of these patients provides new sights into circadian entrainment mechanisms. We therefore examined the circadian rhythm of circulating melatonin and the sleep‐wake rhythm in five patients with chronic sleep‐wake rhythm disorders and ten age‐matched healthy controls. All patients showed altered circadian melatonin rhythm parameters in relation to their sleep‐wake cycle compared to age‐matched controls. These alterations were random, i.e., independent of the type, the duration, and the age of onset of the disorder. The melatonin onset to sleep onset interval varied between the patients and the melatonin acrophase to sleep offset interval was prolonged in four patients. These findings indicate individual phase relations between the circadian melatonin rhythm and the sleep‐wake cycle in patients with chronic sleep‐wake rhythm disorders. Since the prolonged melatonin acrophase to sleep offset interval was the most consistent finding independent of aetiological origins, this abnormality may be one possible maintaining factor in chronic sleep‐wake rhythm disorders due to reduced phase‐resetting properties of the circadian pacemaker. Furthermore, rather low circadian melatonin amplitudes and a subsensitivity to daylight may maintain the disorder in at least some patients.

Journal

Journal of Pineal ResearchWiley

Published: Dec 1, 1998

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off