Brain and Behavior. 2018;8:e01006.
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Alterations of brain network hubs in reflex syncope: Evidence
from a graph theoretical analysis based on DTI
Bong Soo Park
* | Yoo Jin Lee
* | Jin-Han Park
| Il Hwan Kim
Si Hyung Park
| Ho-Joon Lee
| Kang Min Park
provided the original work is properly cited.
©2018TheAuthors. Brain and BehaviorpublishedbyWileyPeriodicals,Inc.
*These authors contributed equally to this work.
Ministry of Science and ICT of the Republic
Objective: We evaluated global topology and organization of regional hubs in the
brain networks and microstructural abnormalities in the white matter of patients
with reflex syncope.
Methods: Twenty patients with reflex syncope and thirty healthy subjects were re-
We then investigated differences in the network measures between the patients
with reflex syncope and the healthy subjects. We also analyzed microstructural ab-
Results: Measures of global topology were not different between patients with re-
jects. The betweenness centrality measures of the left middle orbitofrontal, left
left superior medial frontal gyrus in patients were lower than those in healthy sub-
ferences in the fractional anisotropy and mean diffusivity values between the two
Conclusions: We have identified a reorganization of network hubs in the brain net-
work of patients with reflex syncope. These alterations in brain network may play a
role in the pathophysiologic mechanism underlying reflex syncope.