Allergic reactions to raw, pasteurized, and homogenized/pasteurized cow milk: a comparison

Allergic reactions to raw, pasteurized, and homogenized/pasteurized cow milk: a comparison Five children aged 12‐40 months with IgE‐mediated adverse reactions to cow milk (immediate onset clinical pattern of cow milk allergy) were orally challenged double‐blind in random order with three different milk preparations processed from the same batch of milk 1) raw untreated cow milk, 2) pasteurized cow milk, 3) homogenized and pasteurized cow milk, and 4) Nutramigen®(a commercial hypoallergenic infant formula based on hydrolysed casein) as placebo. Skin prick tests with the same preparations were also performed. On oral challenge the three different processed milk types provoked significant and similar allergic reactions in each child, and no adverse reactions followed the challenge with placebo (Nutramigen). Skin prick test with the same milk products were positive in all children and comparable to the results with an extract of purified raw cow milk protein (Soluprickreg;), whereas Nutramigen did not elicit any skin reactions. A tendency towards a lower threshold of reaction and larger skin reactions induced by the processed milk preparations might indicate an increased ability of pasteurized and homogenized/pasteurized milk to evoke allergic reactions in patients allergic to milk. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Allergy Wiley

Allergic reactions to raw, pasteurized, and homogenized/pasteurized cow milk: a comparison

Allergy, Volume 43 (2) – Feb 1, 1988

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Publisher
Wiley
Copyright
Copyright © 1988 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0105-4538
eISSN
1398-9995
D.O.I.
10.1111/j.1398-9995.1988.tb00404.x
Publisher site
See Article on Publisher Site

Abstract

Five children aged 12‐40 months with IgE‐mediated adverse reactions to cow milk (immediate onset clinical pattern of cow milk allergy) were orally challenged double‐blind in random order with three different milk preparations processed from the same batch of milk 1) raw untreated cow milk, 2) pasteurized cow milk, 3) homogenized and pasteurized cow milk, and 4) Nutramigen®(a commercial hypoallergenic infant formula based on hydrolysed casein) as placebo. Skin prick tests with the same preparations were also performed. On oral challenge the three different processed milk types provoked significant and similar allergic reactions in each child, and no adverse reactions followed the challenge with placebo (Nutramigen). Skin prick test with the same milk products were positive in all children and comparable to the results with an extract of purified raw cow milk protein (Soluprickreg;), whereas Nutramigen did not elicit any skin reactions. A tendency towards a lower threshold of reaction and larger skin reactions induced by the processed milk preparations might indicate an increased ability of pasteurized and homogenized/pasteurized milk to evoke allergic reactions in patients allergic to milk.

Journal

AllergyWiley

Published: Feb 1, 1988

References

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