Albuminuria and Cerebral Small Vessel Disease: A Systematic Review and Meta‐Analysis

Albuminuria and Cerebral Small Vessel Disease: A Systematic Review and Meta‐Analysis Widespread vascular injury in the brain and the ensuing effect on structural and functional connectivity are main contributors to neurocognitive dysfunction. Cerebral small vessel disease (SVD) is responsible for more than 20% of strokes, which are the major contributor to vascular dementia and a potential pathogenetic mechanism to Alzheimer's disease. Investigation of cerebral SVD is possible by observing its effects on the brain parenchyma using magnetic resonance imaging (MRI), including white matter hyperintensities (WMHs), lacunar infarcts (LIs), cerebral microbleeds (CMBs), and enlarged perivascular spaces (EPVSs).Because of the unity of the vasculature, SVD is considered a systemic disorder, and microcirculatory damage in other organs could accompany its occurrence in the brain. The kidney and the brain have similar hemodynamic properties, with low resistance and high circulatory flow. Chronic kidney disease (CKD) has been associated with cerebral SVD and cognitive decline, but in advanced disease stages, factors related to impaired clearance could be the main contributors and confound the association between CKD and SVD.Albuminuria is an early marker of kidney disease, corresponding to a subclinical time‐point when the estimated glomerular filtration rate (eGFR) may have not yet been affected. Albuminuria has been associated with coronary artery disease, stroke, and cardiovascular mortality. Pathophysiologically, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of American Geriatrics Society Wiley

Albuminuria and Cerebral Small Vessel Disease: A Systematic Review and Meta‐Analysis

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Publisher
Wiley
Copyright
© 2018 American Geriatrics Society and Wiley Periodicals, Inc.
ISSN
0002-8614
eISSN
1532-5415
D.O.I.
10.1111/jgs.15240
Publisher site
See Article on Publisher Site

Abstract

Widespread vascular injury in the brain and the ensuing effect on structural and functional connectivity are main contributors to neurocognitive dysfunction. Cerebral small vessel disease (SVD) is responsible for more than 20% of strokes, which are the major contributor to vascular dementia and a potential pathogenetic mechanism to Alzheimer's disease. Investigation of cerebral SVD is possible by observing its effects on the brain parenchyma using magnetic resonance imaging (MRI), including white matter hyperintensities (WMHs), lacunar infarcts (LIs), cerebral microbleeds (CMBs), and enlarged perivascular spaces (EPVSs).Because of the unity of the vasculature, SVD is considered a systemic disorder, and microcirculatory damage in other organs could accompany its occurrence in the brain. The kidney and the brain have similar hemodynamic properties, with low resistance and high circulatory flow. Chronic kidney disease (CKD) has been associated with cerebral SVD and cognitive decline, but in advanced disease stages, factors related to impaired clearance could be the main contributors and confound the association between CKD and SVD.Albuminuria is an early marker of kidney disease, corresponding to a subclinical time‐point when the estimated glomerular filtration rate (eGFR) may have not yet been affected. Albuminuria has been associated with coronary artery disease, stroke, and cardiovascular mortality. Pathophysiologically,

Journal

Journal of American Geriatrics SocietyWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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