IntroductionGastric cancer is the fifth most common malignancy and the third most common cause of cancer‐related deaths worldwide. Most patients with gastric cancer present with advanced unresectable disease. The burden of gastric cancer morbidity and mortality falls largely on the elderly. More than 60% of gastric cancer cases are diagnosed in patients who are 65 years of age or older and more than one‐third of patients are 75 years of age or older.Elderly patients with gastric cancer often receive less aggressive diagnostic evaluation, surgery, and chemotherapy in comparison with their younger counterparts. Patient age is not associated with advanced gastric cancer prognosis, yet many oncologists hesitate recommending systemic chemotherapy to elderly patients. This may be due to a higher likelihood of comorbidities or age‐related changes in pharmacokinetics and pharmacodynamics, which may lead to higher toxicity among elderly patients. Current guidelines lack clarity for the management of gastric cancer in elderly patients, which may play a role in undertreatment of this cohort.The frequency of gastric cancer in young patients is relatively low, with approximately 6% of cases being diagnosed in patients 44 years of age or less. However, a US national study revealed that the annual rate of gastric cancer diagnoses among younger
Journal of Gastroenterology and Hepatology – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera