IntroductionGastric cancer is the fifth most common malignancy and the third most common cause of cancer‐related deaths worldwide. Most patients with gastric cancer present with advanced unresectable disease. The burden of gastric cancer morbidity and mortality falls largely on the elderly. More than 60% of gastric cancer cases are diagnosed in patients who are 65 years of age or older and more than one‐third of patients are 75 years of age or older.Elderly patients with gastric cancer often receive less aggressive diagnostic evaluation, surgery, and chemotherapy in comparison with their younger counterparts. Patient age is not associated with advanced gastric cancer prognosis, yet many oncologists hesitate recommending systemic chemotherapy to elderly patients. This may be due to a higher likelihood of comorbidities or age‐related changes in pharmacokinetics and pharmacodynamics, which may lead to higher toxicity among elderly patients. Current guidelines lack clarity for the management of gastric cancer in elderly patients, which may play a role in undertreatment of this cohort.The frequency of gastric cancer in young patients is relatively low, with approximately 6% of cases being diagnosed in patients 44 years of age or less. However, a US national study revealed that the annual rate of gastric cancer diagnoses among younger
Journal of Gastroenterology and Hepatology – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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