Adsorption of Soluble Immunoglobulin‐Type Adhesion Molecules to Cellulose Acetate Beads

Adsorption of Soluble Immunoglobulin‐Type Adhesion Molecules to Cellulose Acetate Beads Circulating levels of soluble intercellular adhesion molecule‐1 (sICAM‐1) and vascular adhesion molecule‐1 (sVCAM‐1) are elevated in patients with inflammatory bowel disease. Cellulose acetate (CA) beads are used as carriers for granulocyte and monocyte (GM) adsorptive apheresis (GMA). We investigated the effect of CA beads on sICAM‐1 and sVCAM‐1 plasma concentrations in vitro. Because GM adsorption to CA beads increased with a rise in the incubation temperature in our previous study, peripheral blood was incubated with and without CA beads at 5, 25, 37, or 43 °C and plasma sICAM‐1 and sVCAM‐1 was measured. The sICAM‐1 and sVCAM‐1 concentrations in samples incubated with CA beads were significantly lower than those without CA beads at all four temperatures. However, no significant differences were observed both sICAM‐1 and sVCAM‐1 plasma levels at the four different temperatures after incubation with CA beads. These results suggest that independent of incubation temperature, sICAM‐1 and sVCAM‐1 are likely to adsorb CA beads. These molecules may be a new index for predicting the therapeutic effects of GMA. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Therapeutic Apheresis and Dialysis Wiley

Adsorption of Soluble Immunoglobulin‐Type Adhesion Molecules to Cellulose Acetate Beads

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 International Society for Apheresis, Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy
ISSN
1744-9979
eISSN
1744-9987
D.O.I.
10.1111/1744-9987.12693
Publisher site
See Article on Publisher Site

Abstract

Circulating levels of soluble intercellular adhesion molecule‐1 (sICAM‐1) and vascular adhesion molecule‐1 (sVCAM‐1) are elevated in patients with inflammatory bowel disease. Cellulose acetate (CA) beads are used as carriers for granulocyte and monocyte (GM) adsorptive apheresis (GMA). We investigated the effect of CA beads on sICAM‐1 and sVCAM‐1 plasma concentrations in vitro. Because GM adsorption to CA beads increased with a rise in the incubation temperature in our previous study, peripheral blood was incubated with and without CA beads at 5, 25, 37, or 43 °C and plasma sICAM‐1 and sVCAM‐1 was measured. The sICAM‐1 and sVCAM‐1 concentrations in samples incubated with CA beads were significantly lower than those without CA beads at all four temperatures. However, no significant differences were observed both sICAM‐1 and sVCAM‐1 plasma levels at the four different temperatures after incubation with CA beads. These results suggest that independent of incubation temperature, sICAM‐1 and sVCAM‐1 are likely to adsorb CA beads. These molecules may be a new index for predicting the therapeutic effects of GMA.

Journal

Therapeutic Apheresis and DialysisWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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