We have previously demonstrated increased myelination in adult rats that were adrenalectomized (ADX) neonatally. However, Preston and McMorris (1984) recently reported reduced myelination at Day 21 or 22 in day 14 ADX animals. The present experiment attempted to replicate Preston and McMorris' study to determine whether early adrenalectomy might be producing a transient hypomyelination prior to the hypermyelination observed at later time points. We were unable to duplicate the exact protocol of Preston and McMorris (which involved weaning at Day 18 with administration of saline and glucose drinking solutions) because of 100% mortality of our ADX rats by Day 20. However, using our standard mineralocorticoid replacement therapy which allowed the animals to remain with their mothers, all of the ADX rats survived, and we were able to assess myelination in these animals by means of standard biochemical methods. All measures showed absolutely no reduction in myelination in ADX rats compared with sham‐operated controls. The discrepancy between the present results and those of Preston and McMorris are attributed, at least in part, to the early weaning procedure used by these investigators.
Developmental Psychobiology – Wiley
Published: Jul 1, 1985
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera