Adjuvant radiotherapy in sinonasal mucosal melanoma: A retrospective analysis

Adjuvant radiotherapy in sinonasal mucosal melanoma: A retrospective analysis KeypointsSinonasal melanomas.Adjuvant radiotherapy.INTRODUCTIONSinonasal mucosal melanoma is a rare malignancy with a reported incidence rate of 0.05 per 100 000 in the United States. In the Netherlands, this disease accounts for 8% of all sinonasal malignancies. The prognosis is poor, with an estimated 5‐year overall survival (OS) of 21.8%‐40.1%. The aggressive behaviour of this tumour results in advanced disease at diagnosis and high rates of local (38%‐46.6%) and distant recurrence (34.6%‐66%).Due to the low incidence of this disease, the development of a standardised treatment protocol and prognostic models has been difficult. Surgical resection with clear margins has been the key mode of treatment with curative intent. Ideally, all unilateral mucosa should be removed, as this malignancy often presents with multifocal lesions that could easily be missed. However, given the complex anatomy of the sinonasal tract with close relation to vital structures, radical resection is often hard to achieve. In case of incomplete resection, post‐operative radiotherapy is advocated. No consensus has been reached regarding the use of adjuvant radiotherapy: while some studies reported better local control and sometimes even better OS, other studies did not find any difference. The same problem applies for prognostic factors for recurrence and survival: the predictors reported http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Otolaryngology Wiley

Adjuvant radiotherapy in sinonasal mucosal melanoma: A retrospective analysis

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 John Wiley & Sons Ltd
ISSN
1749-4478
eISSN
1749-4486
D.O.I.
10.1111/coa.13033
Publisher site
See Article on Publisher Site

Abstract

KeypointsSinonasal melanomas.Adjuvant radiotherapy.INTRODUCTIONSinonasal mucosal melanoma is a rare malignancy with a reported incidence rate of 0.05 per 100 000 in the United States. In the Netherlands, this disease accounts for 8% of all sinonasal malignancies. The prognosis is poor, with an estimated 5‐year overall survival (OS) of 21.8%‐40.1%. The aggressive behaviour of this tumour results in advanced disease at diagnosis and high rates of local (38%‐46.6%) and distant recurrence (34.6%‐66%).Due to the low incidence of this disease, the development of a standardised treatment protocol and prognostic models has been difficult. Surgical resection with clear margins has been the key mode of treatment with curative intent. Ideally, all unilateral mucosa should be removed, as this malignancy often presents with multifocal lesions that could easily be missed. However, given the complex anatomy of the sinonasal tract with close relation to vital structures, radical resection is often hard to achieve. In case of incomplete resection, post‐operative radiotherapy is advocated. No consensus has been reached regarding the use of adjuvant radiotherapy: while some studies reported better local control and sometimes even better OS, other studies did not find any difference. The same problem applies for prognostic factors for recurrence and survival: the predictors reported

Journal

Clinical OtolaryngologyWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

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