Adipocytes role in the bone marrow niche

Adipocytes role in the bone marrow niche Adipocyte infiltration in the bone marrow follows chemotherapy or irradiation. Previous studies indicate that bone marrow fat cells inhibit hematopoietic stem cell function. Recently, Zhou et al. (2017) using state‐of‐the‐art techniques, including sophisticated Cre/loxP technologies, confocal microscopy, in vivo lineage‐tracing, flow cytometry, and bone marrow transplantation, reveal that adipocytes promote hematopoietic recovery after irradiation. This study challenges the current view of adipocytes as negative regulators of the hematopoietic stem cells niche, and reopens the discussion about adipocytes' roles in the bone marrow. Strikingly, genetic deletion of stem cell factor specifically from adipocytes leads to deficiency in hematopoietic stem cells, and reduces animal survival after myeloablation, The emerging knowledge from this research will be important for the treatment of multiple hematologic disorders. © 2017 International Society for Advancement of Cytometry http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cytometry Wiley
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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 International Society for Advancement of Cytometry
ISSN
1552-4922
eISSN
1552-4930
D.O.I.
10.1002/cyto.a.23301
Publisher site
See Article on Publisher Site

Abstract

Adipocyte infiltration in the bone marrow follows chemotherapy or irradiation. Previous studies indicate that bone marrow fat cells inhibit hematopoietic stem cell function. Recently, Zhou et al. (2017) using state‐of‐the‐art techniques, including sophisticated Cre/loxP technologies, confocal microscopy, in vivo lineage‐tracing, flow cytometry, and bone marrow transplantation, reveal that adipocytes promote hematopoietic recovery after irradiation. This study challenges the current view of adipocytes as negative regulators of the hematopoietic stem cells niche, and reopens the discussion about adipocytes' roles in the bone marrow. Strikingly, genetic deletion of stem cell factor specifically from adipocytes leads to deficiency in hematopoietic stem cells, and reduces animal survival after myeloablation, The emerging knowledge from this research will be important for the treatment of multiple hematologic disorders. © 2017 International Society for Advancement of Cytometry

Journal

CytometryWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

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