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Periodontology 2000, Vol. 23, 2000, 19–49 Co py rig ht C Mu nk sga ard 2 0 0 0 Printed in Denmark Á All rights reserved PER IODON TOLOG Y 2000 ISSN 0906-6713 Acute-phase reactants in infections and inflammatory diseases J EFFREY L . E BERSOLE &D AV I D C APPELLI General overview of the acute-phase of the vasculature with dilation and leakage of blood vessels, particularly at the post-capillary venule. This reaction results in tissue edema, red blood cells extravasation The acute-phase reaction represents an early and and associated redness. These alterations are likely highly complex reaction of the organism to a variety mediated through the release of various inflamma- of injuries such as bacterial, viral or parasitic infec- tory mediators in the inflamed tissues, including re- tion, mechanical or thermal trauma, ischaemic ne- active oxygen species, nitrous oxide and arachidon- crosis, or malignant growth (78). The acute phase re- fers to physiological and metabolic alterations that ensue immediately after onset of infection or tissue injury. A variety of changes in the organism act in concert to neutralize the inflammatory agent and foster healing of damaged tissues. In contrast with the specificity of cellular and humoral immunity,
Periodontology 2000 – Wiley
Published: Jun 1, 2000
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